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Path of Exile 2 (PoE 2)

Poison Explained

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Poison is a Skill Tag in Path of Exile 2 (PoE 2). Read on to learn what skills and gems that have the Poison tag, the affixes, Uniques, and what Poison is!

What is Poison?

Poison In-Game Description

Poison is an Ailment that deals Chaos damage over time and lasts 2 seconds by default. Damage from Poison bypasses Energy Shield.

Physical and Chaos damage from Hits Contribute to Poison Magnitude.

Damage does not Contribute to Poison chance, so it cannot be inflicted without an explicit source of Poison chance. The base Magnitude of Poison is Chaos damage per second dealt by the Hit that inflicted it. This is calculated using the final damage dealt by the Hit, but not any modifiers on the target that affect how much damage they will take from the Hit. This magnitude is not further affected by any modifiers to the damage you deal.

Modifiers and Debuffs that affect the enemy's ability to mitigate damage (such as Shock) can affect the damage the enemy takes from Poison, but any such modifiers that specifically apply to Hit damage (such as Penetration) do not affect Poison damage.

Poison Uniques

Unique Gear with Poison

Name Implicit and Modifiers
AtsakAtsak's Sight Veiled Mask
Helmet
Fixed Modifiers:
・30-40% increased Critical Hit Chance
・+10-20 to Dexterity
・+10-20 to Intelligence
・Critical Hits Poison the enemy
・100-150% increased Evasion and Energy Shield
Lycosidae Rampart Tower Shield ImageLycosidae Rampart Tower Shield
Shield
Grants Skill:
・Raise Shield
Fixed Modifiers:
・30-40% increased Block Chance
・60-100% increased Armour
・Accuracy Rating is Doubled
・Blocking Damage Poisons the enemy as though dealing 100 Base Chaos Damage
QuatlQuatl's Molt Serpentscale Coat
Body Armour
Fixed Modifiers:
・+60-80 to maximum Life
・+17-23% to Chaos Resistance
・10-20 Life Regeneration per second
・Cannot be Poisoned
・60-80% increased Evasion Rating
Plaguefinger Gauze Wraps ImagePlaguefinger Gauze Wraps
Gloves
Fixed Modifiers:
・30-40% increased Evasion and Energy Shield
・4-6% increased Attack Speed
・20-30% chance to Poison on Hit
・All Damage from Hits Contributes to Poison Magnitude
Snakebite Spined Bracers ImageSnakebite Spined Bracers
Gloves
Fixed Modifiers:
・40-60% increased Evasion Rating
・+7-17% to Chaos Resistance
・20-30% chance to Poison on Hit
・Targets can be affected by +1 of your Poisons at the same time
・6-10 Life Regeneration per second

List of Unique Equipment

Poison Affixes

All Affixes with Poison

We're still checking out the affixes. Please come back for more updates!

Poison Skills

Poison in Ascendancy Skills

We're still checking out this skill tag. Please come back for more updates!

List of Ascendancy Skills

Poison in Passives

Skill Effect
Crippling Toxins ImageCrippling Toxins ・25% chance for Attacks to Main on Hit against Poisoned Enemies
・25% increased Magnitude of Poison you inflict
Low Tolerance ImageLow Tolerance ・60% increased Effect of Poison you inflict on targets that are not Poisoned
Stacking Toxins ImageStacking Toxins ・Targets can be affected by +1 of your Poisons at the same time
・20% reduced Magnitude of Poison you inflict
Lasting Toxins ImageLasting Toxins ・10% increased Skill Effect Duration
・50% increased Poison Duration
Leeching Toxins ImageLeeching Toxins ・30% increased Magnitude of Poison you inflict
・Recover 2% of Life on Killing a Poisoned Enemy
Building Toxins ImageBuilding Toxins ・25% reduced Poison Duration
・Targets can be affected by +1 of you Poisons at the same time
Escalating Toxins ImageEscalating Toxins ・10% increased Poison Duration for each Poison you have inflicted Recently, up to a maximum of 100%
Coated Knife ImageCoated Knife ・Critical Hits with Daggers have a 25% chance to Poison the Enemy
Poison Chance ・X% chance to Poison on Hit
Poison Duration ・X% increased Poison Duration
Poison Damage ・X% increased Magnitude of Poison you Inflict

Passive Skill Tree Guide and List of Passives

Poison Gems

All Poison Skill Gems

Gem Effects
Gas Grenade ImageGas Grenade Impact:
・Impact radius is 1.5 meters
・Fuse duration is 2 seconds
Poison Cloud:
・Attack Damage: 128%
・Does not Hit, but Poisons enemies as though Hitting them
・Gains 20% more radius per second, up to a maximum of 80%
・Cloud radius is 1.5 meters
Explosion:
・Attack Damage: 342%
・Converts 100% of Physical Damage to Fire Damage
Poisonburst Arrow ImagePoisonburst Arrow None
Toxic Domain ImageToxic Domain Toxic Bloom:
・Toxic Bloom is 3 metres
・Toxic Bloom duration is 8 seconds
・Each Enemy can have up to 1 Pustule attached
・Regenerate 27.27 Life per Second
・Skill costs are increased by 25%
・Projectile hits attach a Pustule.
Pustule Explosion:
・Attack Damage: 84%
・Always Poisons on Hit
・Pustule Detonation Rradius is 1.6 metres
・Pustule Detonates after 6 seconds
・Pustules store expected Damage of Poisons inflicted on them and will Detonate early after storing 23610 Poison Damage
・Stored Poison grants up to 300% more Explosion Damage.
Toxic Growth ImageToxic Growth Attack:
・0.7 Seconds to Total Attack Time
・Fires 6 Arrows
・Stored Poison adds up to 1.5 metres to base explosion radius
・Stored Poison grants up to 100% more explosion damage
・Explosion Radius is 0.8 metres
・Maximum Pustule Duration is 15 seconds
・Maximum Pustule Limit is 6
Vine Arrow ImageVine Arrow ・Impact Radius is 0.8 Metres

List of Skill Gems

All Poison Support Gems

Gem Effects
Admixture ImageAdmixture ・20% more Magnitude of Bleeding inflicted by Supported Skills against Poisoned Enemies
・20% more Magnitude of Poison Inflicted by Supported Skills against Bleeding Enemies.
Bursting Plague ImageBursting Plague ・Poison from supported skills also adds 200% of damage per second to enemy as Plague, up to a maximum of 10% of enemy's maximum life.
Corrosion ImageCorrosion ・Poison applied by supported skills also break armour equal to 80% of Poison damage dealt.
Deadly Poison I ImageDeadly Poison I ・Supported Skills deal 25% less damage with Hits
・75% more Magnitude of Poison inflicted with Supported Skills
Deadly Poison II ImageDeadly Poison II ・Supported Skills deal 30% less Damage with Hits
・100% more Magnitude of Poison inflicted with Supported Skills
Malady ImageMalady ・Base Bleed chance instead applies to Poison for Supported Skills
・Base Poison chance instead applies to Bleed for Supported Skills
Poison I ImagePoison I ・Supported skills have 40% chance to Poison on hit
Poison II ImagePoison II ・Supported Skills have 60% chance to Poison on Hit
Poison III ImagePoison III ・Supported Skills have 60% chance to Poison on Hit
・20% more magnitude of Poison inflicted by Supported Skills against Bleeding Enemies.

List of Support Gems

All Poison Spirit Gems

Gem Effects
Herald of Plague ImageHerald of Plague ・Spreads the most damaging Poison on enemies you kill in a 1.7 metre radius
・22% chance to hinder enemies on spreading Poison on them
Plague Bearer ImagePlague Bearer ・Stores 4% of Expected Poison damage
・Stores up to 197 Poison Damage
Ravenous Swarm ImageRavenous Swarm ・Swarms attack within 4 metre radius of you
・Swarm duration is 6.6 seconds
・Spawn a new Swarm once every 6 seconds
・Limit active 3 Swarms.

List of Spirit Gems

Path of Exile 2 Related Guides

Path of Exile 2 (PoE 2) Glossary

Glossary and Basic Game Mechanics

All Glossary Guides

Adding to Stat Totals Aftershocks Ailment
Ammunition Ancestral Boost AoE
Arcane Surge Armour Armour Break
Attack Aura Blind
Block Buff Chaining
Channelling Chaos Chill
Chilled Ground Cold Combo
Concentration Corpses Covered in Oil
Critical Damage Bonus Critical Hits Crossbow Ammunition Skills
Crushing Blows Culling Strike Curse
Damage Conversion Damage Gained as Extra Daze
Debuff Decimating Strike Detonator
Dexterity Dual Wielding Duration
Effect Consumption Empowered Skills Energy Shield
Evasion Exposure Fire
Flame of Chayula Freeze Grenade
Guard Heavy Stun Herald
Hit Damage Ignite Ignited Ground
Intelligence Iron Grip Iron Will
Jagged Ground Knockback Life Leech
Life Recharge Lightning Magic Find
Magnitude Mark Melee
Meta Minion Minion Commands
Nova Onslaught Orb
Payoff Persistent Physical
Pierce Pinned Poison
Primed for Stun Projectile Resistance
Reviving Minions Rhoa Mount Shield
Shock Shocked Ground Slam
Spell Spirit Strength
Strike Stun Sustained
Tailwind Totem Travel
Trigger Unholy Might Warcry

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