There are missable character upgrades and quests as well as permanent one-time decisions to make in Path of Exile 2 (PoE 2). Check out this guide for all the missable content and important decisions you need to be aware of in the game!

List of Missables and One-Time Events

Missable Quests and One-Time Events
Class and Ascendancy Selection Socketing Runes and Soul Cores Salvaging and Disenchanting Gear Permanent Bonuses and Unlocks Missable Quests

Class and Ascendancy Selection

The class you choose for your character at the beginning of the game can never be changed after you start. The same goes when choosing an Ascendancy Class, there is no way to change ascendancies right now during Early Access.

List of Classes and Ascendancies

Socketing Runes and Soul Cores

Socketing equipment with Runes and Soul Cores is also a permanent decision. You won't be able to remove or replace the socketed rune or soul core even if you salvage or disenchant the item.

Sockets Explained

Salvaging and Disenchanting Gear

Salvaging gear cannot be undone causing you to lose the salvaged items forever. Be careful when mass salvaging a lot of your stuff so that you won't accidentally salvage the ones that you want to use.

Should You Sell, Salvage or Disenchant Equipment?

Permanent Bonuses and Unlocks

Permanent bonuses such as extra Spirit, Weapon Set Skill Points, maximum Life, Resistances, and other stats can be earned as rewards from Quests and/or defeating certain optional Bosses. These objectives are typically not part of the main questline so you'll have to go out of your way to find them.

List of Permanent Buffs from the Campaign

Unlocking the Salvage and Reforging Bench

The Salvage Bench can only be unlocked after completing the Finding the Forge side quest in Act 1 while the Reforging Bench is unlocked after the Treasures of Utzaal side quest in Act 3.

Missable Quests

There are certain quests that cannot be tracked and do not appear in the quest log. These include the Trial of the Sekhemas and the Trial of Chaos which are really important to do for the progression of your character.

List of All Quests and Quest Rewards

Path of Exile 2 (PoE 2) Related Guides

Beginner's Guide

Gameplay Mechanics

Game and Character Progression

Gear and Crafting

Stats and Skills Guides

Settings and Multiplayer