Path of Exile 2 (PoE 2)

Heart Tissue Passive Effects and How to Get

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Heart Tissue is a Notable Passive in Path of Exile 2 (PoE 2). See an overview of Heart Tissue, including its effects and how to get it.

List of Contents

Heart Tissue Overview

Passive Effect and Type

Heart Tissue Icon Heart Tissue Type
Notable
Effects
・6% of Damage taken Recouped as Life
・Regenerate 0.4% of Life per second if you have been Hit Recently

How to Get Heart Tissue

Progress the Passive Tree

Path of Exile 2 Progress Passive Tree

Naturally, the easiest way to get the Heart Tissue Notable passive is to progress through the Passive Tree itself as you level up.

Leveling Guide: How to Get XP Fast

Slot in a Megalomaniac Diamond

Megalomaniac Diamond Icon Megalomaniac Diamond Type
Jewel
Description
Allocates 2-3 Random Notable Passive Skill

Defeating Kosis, the Revelation can get a Megalomaniac Diamond that allocates the Heart Tissue passive alongside other Notable Passives upon getting slotted into a Jewel Socket.

Delirium Guide

Instill an Amulet with the Correct Distilled Emotion Combination

Distilled Emotions Recipe
Distilled Paranoia ImageDistilled Paranoia Distilled Despair ImageDistilled Despair Distilled Ire ImageDistilled Ire

You can anoint your equipped amulet with an exact combination of Distilled Emotions to get the Heart Tissue notable passive without progressing the Passive Tree.

Distilled Emotions are obtained during the Derilium endgame mechanic, with the more crucial emotions only being able to drop upon building up the emotions bar to high levels!

List of Distilled Emotions

Path of Exile 2 (PoE 2) Related Guides

Passive Skills

Passive Skill Tree Guide and List of Passives

List of All Passive Skill Types

Passive Skill Type
Keystone Notable Small

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