Path of Exile 2 (PoE 2)

Natural Immunity Passive Effects and How to Get

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Natural Immunity is a Notable Passive in Path of Exile 2 (PoE 2). See an overview of Natural Immunity, including its effects and how to get it.

List of Contents

Natural Immunity Overview

Passive Effect and Type

Natural Immunity Icon Natural Immunity Type
Notable
Effects
・+4 to Ailment Threshold per Dexterity

How to Get Natural Immunity

Progress the Passive Tree

Path of Exile 2 Progress Passive Tree

Naturally, the easiest way to get the Natural Immunity Notable passive is to progress through the Passive Tree itself as you level up.

The closest class that can access Natural Immunity quickly is the Mercenary class.

Leveling Guide: How to Get XP Fast

Slot in a Megalomaniac Diamond

Megalomaniac Diamond Icon Megalomaniac Diamond Type
Jewel
Description
Allocates 2-3 Random Notable Passive Skill

Defeating Kosis, the Revelation can get a Megalomaniac Diamond that allocates the Natural Immunity passive alongside other Notable Passives upon getting slotted into a Jewel Socket.

Delirium Guide

Instill an Amulet with the Correct Distilled Emotion Combination

Distilled Emotions Recipe
Distilled Greed ImageDistilled Greed Distilled Suffering ImageDistilled Suffering Distilled Paranoia ImageDistilled Paranoia

You can anoint your equipped amulet with an exact combination of Distilled Emotions to get the Natural Immunity notable passive without progressing the Passive Tree.

Distilled Emotions are obtained during the Derilium endgame mechanic, with the more crucial emotions only being able to drop upon building up the emotions bar to high levels!

List of Distilled Emotions

Path of Exile 2 (PoE 2) Related Guides

Passive Skills

Passive Skill Tree Guide and List of Passives

List of All Passive Skill Types

Passive Skill Type
Keystone Notable Small

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