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This is a tier list of the best Vampiric Powers to use for endgame builds in Diablo 4 (D4) Season 2. Read on to see a list of the best Vampiric Powers in the game and the best ones to equip for your character.
| Vampiric Powers Guides | |
|---|---|
| List of Vampiric Powers | Best Vampiric Powers Tier List |
| Vampiric Curse Explained | - |
List of Contents
| Tier List Per Tier | |||
|---|---|---|---|
| S Tier | A Tier | B Tier | C Tier |
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| Tier List Explanations | |||
|---|---|---|---|
| S Tier | A Tier | B Tier | C Tier |
| Power | Explanation |
|---|---|
 Prey on the Weak
|
Vulnerable has always been a strong damage multiplier and Prey on the Weak just adds more to this. There's nothing much to talk about Prey on the Weak aside from its a straight up damage buff and even if your build cannot apply vulnerable, there are multitude of ways to apply Vampiric Curse in Season 2 which allows this Power to still shine. |
 Metamorphosis
|
One of the easiest way to apply Vampiric Curse. This is a guaranteed application and all you need to do to trigger it is to use your dodge skill which is free. The damage is not the main deal of this power but its guaranteed effect to apply Vampiric Curse which can greatly synergize with several Vampiric Curses in the game. |
| Vampiric Power/ Cost | Effects / How to Get |
|---|---|
| Prey on the Weak 2 | 0 | 0 | You deal 16% increased damage to Vulnerable enemies. Enemies are Vulnerable while affected by a Vampiric Curse from your other Vampiric Powers. Spend Potent Blood to unlock |
| Metamorphosis 2 | 2 | 2 | When you Evade you turn into a cloud of bats, becoming Unstoppable for 4 seconds. Enemies along your path take 160% Physical damage and are inflicted with Vampiric Curse. Acquired from A Serpent Cornered, Quest #9 of the Season 2 Questline |
| Power | Explanation |
|---|---|
 Domination
|
Similar case to Prey on the Weak except it applies to stun which not all characters can easily apply. However, if your character can apply Stun, this Vampiric Power is easily an S tier power. |
 Hemomancy
|
Hemomancy is an insane power farming Vampiric Power during the early game. However, it does fall off in the later stages of the game but we still put it in at A tier due to its low Cooldown and its ability to heal the player for 1% of every target. It's also misleading with the “nearby targets” as it easily hits all enemies even outside your current screen which still makes it a great durability rune if you need some survivability in the later stages of the game. |
 Sanguine Brace
|
A must have power for Overpower builds. |
 Accursed Touch
|
This is an easy way for DoT builds with high lucky hit chance to spread Vampiric Curse and if you have Prey on the Weak, apply vulnerable to a huge enemy group. |
 Bathe in Blood
|
Despite the pool having an 8 second cooldown, Bathe in Blood is a strong Power to have for units that rely on channeling skills. This makes skills like Rapid Fire have more power as its a straight 40% damage buff as long as you don't stop channeling in the pool of blood. |
 Blood Boil
|
Adds a secondary source of damage for Overpower Builds. The extra guaranteed Overpower is also a nice addition. |
 Flowing Veins
|
Synergizes greatly with Accursed Touch and 60% flat increase to lucky hit + DoT builds. |
| Vampiric Power/ Cost | Effects / How to Get |
|---|---|
| Domination 1 | 0 | 0 | You deal 24% increased damage to enemies who are Stunned, Immobilized, Frozen, or Feared. If they're also Injured and not an Elite, they're instantly killed. Spend Potent Blood to unlock |
| Hemomancy 0 | 0 | 3 | Your attacks deal 80% of your Maximum Life as Physical damage to nearby enemies. This can only occur once every 4 seconds. You heal for 1% of your Maximum Life for each enemy damaged this way. Spend Potent Blood to unlock |
| Sanguine Brace 0 | 1 | 1 | When you kill an enemy, Fortify for 6% of your Base Life. While you have more Fortify than half of your Maximum Life, you gain 8% Critical Strike Chance. Tier 4 of Hunter's Acclaim Board rewards |
| Accursed Touch 0 | 6 | 0 | Lucky Hit: Up to a 44% chance to inflict Vampiric Curse on enemies. Enemies with the Vampiric Curse have a 15% chance to spread it to other surrounding enemies. Accursed Souls deal 200% increased damage. Tier 9 of Hunter's Acclaim Board rewards |
| Bathe in Blood 0 | 3 | 3 | While Channeling a Skill, you form a pool of blood beneath you. While channeling a skill in a pool, your Channeled Skills deal 40% increased damage and you gain 30% Damage Reduction. A pool can only form once every 8 seconds. Spend Potent Blood to unlock |
| Blood Boil 0 | 0 | 6 | When your Core Skills Overpower an enemy, you spawn 3 Volatile Blood Drops. Collecting a Volatile Blood Drop causes it to explode, dealing 60% Physical damage around you. Every 20 seconds, your next Skill is guaranteed to Overpower. Spend Potent Blood to unlock |
| Flowing Veins 2 | 2 | 2 | You deal 60% increased Damage Over Time to enemies that are moving or affected by a Vampiric Curse. Spend Potent Blood to unlock |
| Power | Explanation |
|---|---|
 Coven’s Fangs
|
The bat attacks are not the highlight of this power but its ability to apply Vampiric Curse to enemies. If you are playing a build that can reliably apply this rune such as a necromancer summoner build, this power can be a good power to consider but without a reliable way to trigger this power, it becomes a very low tier power. |
 Feed the Coven
|
Similar to Coven's Fangs. If you have a reliable way to trigger Feed the Coven then it can be a good way to keep your resources up to allow more core skill usage which translates to a direct DPS increase. |
 Terror
|
A great power for melee builds. While the guaranteed critical strikes against feared enemies are great, the chance to fear enemies who attack you is a straight up durability buff. |
 Moonrise
|
A great power to get some free attack speed. Can be a viable power to include for builds like an Arc Lash Wizard build as it can allow an almost triple damage increase for your primary attacks. |
| Vampiric Power/ Cost | Effects / How to Get |
|---|---|
| Coven’s Fangs 0 | 2 | 0 | Your Conjuration, Companion, Minion, and Bat Familiar attacks deal 52% increased damage to Crowd Controlled enemies. Lucky Hit: Your Conjuration, Companion, Minion, and Bat Familiar have up to a 30% chance to inflict Vampiric Curse when hitting enemies. Spend Potent Blood to unlock |
| Feed the Coven 0 | 0 | 1 | Lucky Hit: Conjuration, Companion, Minion and Bat Familiar attacks have up to a 60% chance to restore 10 Primary Resource to you and increase your Damage by 10% for 4 seconds. Spend Potent Blood to unlock |
| Terror 1 | 1 | 1 | When struck, you have a 14% chance to Fear nearby enemies and Slow them by 80% for 2 seconds. You are guaranteed to Critically Strike enemies who are Feared. Spend Potent Blood to unlock |
| Moonrise 6 | 0 | 0 | Hitting an enemy with a Basic Skill grants you 4% Attack Speed for 10 seconds, stacking up to 5 times. Upon reaching maximum stacks, you enter a Vampiric Bloodrage, gaining 160% Basic Skill damage and 15% Movement Speed for 10 seconds. Acquired from Battle of Fear and Faith, Quest #7 of the Season 2 Questline |
| Power | Explanation |
|---|---|
 Anticipation
|
Ultimate skills are pretty decent and this is a straight 20% cooldown reduction for it. However, to maximize its value, you'll need to rely to DoT but most DoT builds don't rely on Ultimates to deal damage which makes this a low tier Power with better alternatives. |
 Hectic
|
Very random proc chance and you need to launch several primary just to make it work. |
 Infection
|
Very hesitant to place it to C tier as it deserves a lower tier. This power does not apply to DoT and attacks with multiple hits which means you'll have to launch 8 different attacks just to trigger this power for a measly 70% damage. |
 Jagged Spikes
|
Very low chance and thorns has always had a low damage rate due to its actual low thorn value and the enemy's attack rate. Might have a place for specialized thorns build. |
 Rampart
|
Requires you to be idle for 3 seconds to work which essentially means death in higher tiers. |
 Ravenous
|
An almost good Vampiric Power but it does need a high amount of Movement Speed and lucky hit. Very hard to utilize due to its lucky hit chance and subpar effect. |
 Resilience
|
Most attacks will end up killing you in one hit at higher tiers which means this is an unusable power. |
 Undying
|
Very low healing value. |
 Call Familiar
|
Very few skills to apply this and a very low stun rate as well and its target being random makes it a very clunky power to have. |
| Vampiric Power/ Cost | Effects / How to Get |
|---|---|
| Anticipation 0 | 1 | 0 | Your Ultimate Skills gain 20% Cooldown Reduction. Your Ultimate Skills gain 12% increased damage for each nearby enemy affected by your Damage Over Time effects. Spend Potent Blood to unlock |
| Hectic 0 | 3 | 0 | For every 5 Basic Skills you cast, one of your active Cooldowns is reduced by 2 seconds. Acquired from Beckoning Thirst, Quest #5 of the Season 2 Questline |
| Infection 1 | 0 | 0 | Hitting enemies with direct damage infects them with Pox. Inflicting Pox 8 times on an enemy expunges their infection, dealing 70% Poison damage. Spend Potent Blood to unlock |
| Jagged Spikes 1 | 1 | 0 | Thorns have a 10% chance to deal 300% increased damage and Chill enemies for 8%. Spend Potent Blood to unlock |
| Rampart 0 | 1 | 1 | After not moving for 3 seconds, you gain a Barrier for 40% of your Maximum Life for 6 seconds. This effect can occur once every 20 seconds. Spend Potent Blood to unlock |
| Ravenous 3 | 0 | 0 | Lucky Hit: Up to a 20% chance to increase your Attack Speed by 40% of your Total Movement Speed for 6 seconds. Acquired from A Witness in the Dust, Quest #4 of the Season 2 Questline |
| Resilience 0 | 0 | 2 | You gain 1% Damage Reduction for each 2% Life you are missing. Spend Potent Blood to unlock |
| Undying 0 | 0 | 1 | Casting Skills heals you for 3% Life. Double this bonus while below 50% Life. Acquired from Blood Money, Quest #1 of the Season 2 Questline |
| Call Familiar 3 | 3 | 0 | Casting a Mastery, Weapon Mastery, Macabre, Wrath, or Imbuement Skill calls a bat ally to attack nearby enemies, dealing 80% Physical damage with a 30% chance to Stun. Spend Potent Blood to unlock |
List of Seasons: How Do Seasons Work?
Best Vampiric Powers Tier List
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