Best Runeword Combinations

This lists all the best Runeword combinations in Diablo 4 Vessel of Hatred (D4). Learn more about the best runes to combine and their top build synergies!

Best Runeword Combinations

Tam and Ohm

TamOhm is a strong rune combination in the game as majority of the builds in the game spam core skills, allowing players to stack offerings from Tam quickly. Ohm is the chosen Invocation Rune as its damage increase easily skyrockets any build's capabilities.

Feo and Ner

FeoNer is a great rune combination for survivability and removing impairment effects. Feo grants 1000 offering whenever you're injured or crowd controlled; this gives you enough offerings to activate Ner which evokes the Rogue's Countering Concealment.

This rune combination allows you to dispell any crowd control applied to you, with the added bonus of invincibility and increased dodge chance and mobility.

Tam and Mot

TamMot is a rune combination for builds lacking in Damage Reduction, an ideal affix for pushing the defense of your builds in higher difficulties. This works well with majority of builds that spam core skills a lot, passively granting them damage reduction from Dark Shroud.

How to Make a Good Runeword Combination

Use Ritual Runes with Easy Conditions

Use Ritual runes that have easy conditions to stack offerings fast. The Runewords you choose is entirely dependent on your build, so having Ritual Runes tied to your build playstyle will allow you to apply the effects of your Invocation Runes more often.

List of All Runewords

Runewords Should Improve Builds

Your Runewords should improve on your builds in a sense that it covers the weaknesses of your build, or significantly increases its effectiveness. For example, if your build does not have a Skill or Aspect that can remove crowd control effects, then Feo and Ner can take care of that problem for you.

Best Vessel of Hatred Builds for Season 6

Diablo 4 Related Guides

List of All Runewords

Runeword Guides