In the Resident Evil 4 Remake (RE4), knowing the best loadout allows you to maximize your firepower while making the most of your inventory space. Check out our recommended best loadouts from the early game to the late game!

Best Late Game Loadout

Endgame All-Rounder

Suggested Late Game Loadout
Handgun	SMG	Assault Rifle	Magnum
Red9	LE 5	Stingray	Killer7
How to Use
▶ Use the Red9 to take down weaker threats like Ganados, and Parasites. ▶ Combine the Stingray with the Biometric Sensor to deal with Regenerators. ▶ Use the LE 5 to quickly gun down nearby foes and track down fast-moving enemies like the Novistador. ▶ Save the Killer7 for dealing massive damage against the Island's numerous resilient enemies and bosses. ▶ Stick to the Striker and Broken Butterfly until you get the Killer7 and LE 5.

Loadout Explanation and Suggestions

Like the previous loadouts, this spread of guns is meant to excel at every range and deal with the unique enemies that appear on the Island. It also has a solid balance of crowd control and massive weak point damage due to the addition of the LE 5 and Killer7.

However, we also recommend keeping your Striker handy in case you need more close-range firepower and crowd control, and upgrading to the Fighting Knife after beating Krauser in Chapter 14.

As always, we highly suggest bringing a healthy supply of Hand Grenades and Flash Grenades to supplement your crowd control and help get yourself out of difficult situations.

Best Mid Game Loadout

Mid Game Castle Crasher

Suggested Mid Game Loadout
Handgun	Shotgun	Assault Rifle	Magnum
Red9	Striker	Stingray	Broken Butterfly
How to Use
▶ Use the Red9 to take down common threats like Zealots, Ganados, and Zombie Dogs. ▶ Save the Striker and Broken Butterfly for dealing with resilient enemies like the Armadura and Shielded Zealots. ▶ Use the Stingray to snipe enemies from far away and land high-damage weak point shots against the Castle's bosses. ▶ Stick to the TMP, Riot Gun, and SR M1903 until you get the Broken Butterfly, Striker, and Stingray.

Loadout Explanation and Suggestions

This loadout prioritizes having weapons that cover every range and work well for dealing with the new foes that appear inside the Castle. In addition, it also only features weapons from Chapters 7 to 12.

However, we also recommend keeping a Bolt Thrower handy as an alternative weapon. Its silent Bolts work well for dealing with the Garrador, and its Attachable Mines are a potent option for taking down Shielded Zealots.

In addition, as previously suggested, we also recommend maxing out your Combat Knife's Durability and keeping at least two Hand Grenades and Flash Grenades handy for particularly difficult situations.

Best Early Game Loadout

Pre-Castle All-Rounder

Suggested Early Game Loadout
Handgun	Shotgun	Sniper Rifle	SMG
Red9	Riot Gun	SR M1903	TMP
How to Use
▶ Use the Red9 to take down common threats like Ganados and Zombie Dogs. ▶ Save the Riot Gun and TMP for dealing with groups of foes surrounding you and any resilient enemy that gets too close. ▶ Use the SR M1903 to snipe enemies from far away and land high-damage weak point shots against stronger foes like Chainsaw Men and Minotaurs. ▶ Stick to the SG 09 R and W-870 as your Handgun and Shotgun options until you get the Red9 and Riot Gun.

Loadout Explanation and Suggestions

This loadout emphasizes having a well-balanced spread of guns for every situation before entering the Castle and only features weapons from Chapters 1 to 6.

On top of these weapons, we also recommend maxing out your Combat Knife's Durability and keeping at least two Hand Grenades and Flash Grenades handy for particularly difficult situations.

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