★ Separate Ways DLC Guide Hub
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☆ Ada and Wesker have joined Mercenaries Mode!
★ VR Mode arrives in Winter 2023!
☆ Learn the best ways to speedrun & reach Professional S+!
★ Discover all the Skips you can make in a single playthrough!
In the Resident Evil 4 Remake (RE4), players are limited to 15 saves when aiming for an S+ Rank in Professional Mode. Check out the best save points you should use when playing on Professional!
| Save # | Story Section |
|---|---|
| 1 | After defeating Del Lago (Chapter 4) |
| 2 |  After retrieving Ashley from the Church (Chapter 5) |
| 3 |  Before the Chainsaw Sisters encounter (Chapter 6) |
| 4 |  Before the Mendez boss fight (Chapter 6) |
| 5 |  Before the Water Hall (Chapter 7) |
| 6 |  After the Armored El Gigante (Chapter 8) |
| 7 | After the Ashley segment in Chapter 9 (Start of Chapter 10) |
| 8 |  Before the Verdugo encounter (Chapter 10) |
| 9 |  Before the Minecart section (Chapter 11) |
| 10 | Before the first Krauser fight (Chapter 11) |
| 11 |  Before the Salazar fight (Chapter 12) |
| 12 | After the Regenerator section in Chapter 13 (Start of Chapter 14) |
| 13 |  Before the Transformed Krauser fight (Chapter 14) |
| 14 | End of Chapter 15 |
| 15 |  Before the Saddler fight (Chapter 16) |
| Professional Save Point Tips and Strategies |
|---|
|
|
When going through Professional Mode, we recommend prioritizing using your saves right before boss encounters, especially if you're aiming for an S+ Rank. Since autosaves are disabled and boss fights are usually the most difficult sections of each chapter, it's best to save your progress at these points in the game.
We also recommend saving before difficult chapter sections where you're likely to die or get a game over, such as the Chainsaw Sisters encounter in Chapter 6 and the Water Hall room in Chapter 7.
You should also consider saving after significant weapon upgrades, such as getting your Exclusive Upgrades for the Chicago Sweeper and Primal Knife. Saving at these points in the game will let you retry sections while retaining every major power-up you've purchased and picked up.
Best Exclusive Weapon Upgrades
If you're confident with the number of remaining saves you have, or if you're not aiming for S+ Rank and want to backtrack, you can also consider saving at points of no return, as they usually mark the beginning of a major section that could be difficult to get through.
List of Missables and Points of No Return
Tips and Tricks: A Beginner's Guide
Best Save Points on Professional
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