Resident Evil 4 Remake (RE4) won't be complete without strong bosses like Bitores Mendez, Ramon Salazar, Saddler, and more! Learn more about these bosses and find the best strategy to beat them!

Enemies and Bosses
Enemies and Monsters	Bosses

List of All Bosses

All Resident Evil Remake 4 Bosses In Order
Del Lago Chapter 3	El Gigante Chapter 4	Chainsaw Sisters Chapter 6
Mendez Chapter 6	Armored El Gigante Chapter 8	Verdugo Chapter 10
Dos Gigantes Chapter 11	Krauser Chapter 11	Salazar Chapter 12
Krauser (Transformed) Chapter 14	Saddler Chapter 16	-

Del Lago

Rewards	None
Chapter	Chapter 3

Del Lago is a monster that is encountered while crossing the lake. It can be brought down by multiple harpoons, but the monster's ability to submerge makes this task hard.

How to Defeat Del Lago

• Use Harpoons to attack and hit its body
• Maneuver the boat to avoid obstacles
• Attack its mouth while it's charging towards you

How to Beat Del Lago: Fish Boss Fight Guide

El Gigante

Rewards	Yellow Diamond
First Chapter Appearance	Chapter 4

El Gigante, or "The Giant" is another elite enemy that is first encountered on the way back to the church. This enemy has high durability, but can be taken down easily once the plaga on its back is exposed.

How to Beat El Gigante

• Keep an eye on screen prompts
• Shoot its head until it's staggered
• Knife or shoot the plaga

How to Beat El Gigante (The Giant)

Chainsaw Sisters

First Chapter Appearance	Chapter 6

Chainsaw Sisters are villagers that uses red chainsaws in the village. They will appear at the same time, so use items and weapons that can hit them both during the first seconds of the battle to quickly kill them.

How to Beat Chainsaw Sisters

• Command Ashley to hide
• Throw Grenades as soon as the battle starts
• Use a Shotgun or TMP

How to Beat Chainsaw Sisters

Mendez

Rewards	Mendez's False Eye
Chapter	Chapter 6

The first major threat against Leon's quest, Mendez oversees all activities in the village and is one of the first enemies with control over their mutation. Explosives may put Mendez to the ground, but his mobility may need special attention from standard guns.

How to Defeat Mendez

• Run around and shoot when you get the chance
• Use Incendiary Grenades
• Go up the 2nd floor for a better angle in the 2nd Phase

How to Beat Mendez: Boss Fight Guide

Armored El Gigante

Rewards	None
First Chapter Appearance	Chapter 8

Armored El Gigante is the giant that's wearing full armor except for its head. It will be hard to kill it without exposing its weakpoint — the Plaga on its back that's covered with metal plates.

How to Beat Armored El Gigante

• Shoot it using the Cannon (1st Fight)
• Hide behind covers to avoid thrown objects (1st Fight)
• Shoot the Explosive behind its back (2nd Fight)
• Drop it on the Lava (2nd Fight)

How to Beat Armored El Gigante

Verdugo

Rewards	Gold Monocle
Chapter	Chapter 10

Ramon Salazar's loyal servant, Verdugo serves as an executioner like its name implies. Its bug-like features include an exoskeleton that can block bullets, but it's weak against severe cold brought by nitrogen.

How to Defeat Verdugo

• Use the Nitrogen Pipes to make it vulnerable to attacks
• Watch out and dodge the attacks
• Utilize Melee Prompts

How to Beat Verdugo: Boss Fight Guide

Dos Gigantes

Rewards	Red Beryl (Armored El Gigante), Yellow Diamond (El Gigante)
First Chapter Appearance	Chapter 11

Dos Gigantes are elite, giant enemies you will encounter on the mines. The Armored El Gigante is the one you encountered at the early stages in the castle, but the regular El Gigante is a new variant and not the one you faced with the Dog.

How to Beat Dos Gigantes

• Kill the regular El Gigante first
• Shoot the Explosives placed by Luis
• Drop the Armored El Gigante into the Lava Pit

How to Beat Dos Gigantes

Krauser

Rewards	None
Chapter	Chapter 11

Previously Leon's mentor, Krauser turned to the Los Illuminados for power, one he sought after the events of Racoon City. Krauser is an extremely skilled soldier with mastery in close combat, covert, demolitions, and assault tactics. Leon's only way of fighting him is soldier against soldier.

How to Defeat Krauser (1st & 2nd Encounter)

• Watch the buttons appear and press them
• Parry his attacks to avoid getting hit
• Switch Between Melee and Guns
• Shoot Tripwires When He's Near
• Destroy the Automatic Gun Cameras
• Use Covers When He's Shooting

How to Beat Krauser: Boss Fight Guide

Salazar

Rewards	Lip Rouge
Chapter	Chapter 12

The despicable lord of the castle and the disgrace of the Salazar family, Ramon Salazar brought the power of Las Plagas in his family home and onto his servants, executing all who refuse. Salazar's mutated body can travel through anywhere but tight spaces, and is fragile when Salazar's body is hit.

How to Defeat Salazar

• Focus on shooting its eye and body
• Use SMGs or Magnum as your weapons

How to Beat Salazar: Boss Fight Guide

Krauser (Transformed)

Rewards	Fighting Knife
Chapter	Chapter 14

Krauser, having failed to kill Leon as a soldier, now relies on the power of the Las Plagas to finish the job. In his mutated form, Krauser bolder and tougher but is far slower which makes his attacks easy to dodge.

How to Defeat Krauser (3rd Encounter)

• Stock Up on Items
• Use Shotgun or Fully Automatic Weapons
• Avoid the Middle Area When He's Leaping

How to Beat Krauser (Transformed)

Saddler

Rewards	None
Chapter	Chapter 16

The herald of Las Plagas, Saddler aims to infect the entire world with Plaga and sieze control. His mutated body and control over other creatures with Plaga make him hard to bring down, but his weak spots are easy to shoot and his main body is extremely weak to high explosives.

How to Defeat Saddler

• Focus on shooting its eyes
• Use Explosive Barrels to deal damage
• Hit the Golden Orb During the Final Phase
• Use the Rocket Launcher to End the Fight

How to Beat Saddler: Final Boss Fight Guide

All Boss Skips

Mendez Boss Fight Skip

Update 4/23: This scope glitch has been fixed as of the Ver. 1.05 update and will no longer work.

You can entirely skip the boss fight against Mendez during the last stretch of Chapter 6.

You can do this by glitching through the wall using the autosave and Sniper with a Scope trick. Go up the stairs and come back down once Ashley starts speaking. Head to the first 5 steps of the stairs and aim your scope to the railings while going to the left. Stop moving once you're near the first step and then load your autosave.

After loading, you will be glitched into the wall and you can start walking through it. Follow the wall on the Merchant's side until you reach the solid wall, then go left and you'll be out of range for the boss fight. Ignore the transformed Mendez on the way and go straight to the castle to trigger the cutscene and end the chapter!
How to Beat Mendez: Mendez Boss Fight Guide

No Achievement or Trophy This Way

Silver	Grilled Big Cheese
	Defeat Bitores Méndez.

Note that you won't be able to get Grilled Big Cheese trophy if you do this on your very first playthrough of the game.
Achievements List and Trophy Guide

Missing Bosses From Original

U-3 Removed From the Island Chapter

U-3 and its boss fight was not included in the remake's Main Story Chapters. Even though he doesn't made an appearance, he was still mentioned on a file named Chronicles of Pursuit 2, written by Isidro Uriarte Talavera .

Where is the U-3? Missing Boss Fight

Resident Evil 4 Remake (RE4) Related Guides

Resident Evil 4 Remake Guide and Walkthrough

Resident Evil 4 Remake Wiki
Separate Ways	Story Walkthrough
Requests	Mercenaries Mode
Puzzles	Collectibles
Interactive Map	Tips and Tricks
Weapons	Items
Bosses	Enemies and Monsters
Keys and Locks	Secrets
Characters	News and Game Info