The Resident Evil 4 Remake (RE4) has no chapter select feature, meaning there are plenty of missables and points of no return throughout the game. Check out a list of all missables and learn about all points of no return in the remake!

List of Missables

Missables in the Resident Evil 4 Remake
All Region-Specific Items Clockwork Castellans Requests Treasures

All Region-Specific Items

All items that are exclusively found in each of the three major areas (Village, Castle, and Island) are considered missable. The game has no chapter select feature, nor any way to return to the previous area, so ensure that you've collected everything needed before progressing to the next region.

However, weapons and other items sold by the Merchant are not missable, as you can still buy them from him in every shop found later in the game.

Clockwork Castellans

Clockwork Castellans are easy-to-miss collectibles scattered throughout the Resident Evil 4 Remake. There's always one Castellan that you can find per chapter, so keep an open eye and ear out for them as you play through the game.

All Clockwork Castellans Locations

Requests

Requests are optional side missions that you can find throughout a chapter. These include requests for the Blue Medallion collectibles.

You can only complete the objectives for each Request in the same chapter you found them, meaning they must be finished before moving on to the next chapter.

All Requests Locations

Treasures

There are treasures scattered around every area of the game, usually found inside chests, drawers, and barrels. All of these valuable items are missable, as you cannot go back to them after progressing to the next region.

List of Treasures

All Points of No Return

Village Points of No Return

Chapter 4 - Head for the Church

Leaving the Quarry after the El Gigante fight in Chapter 4 is a point of no return, as you will not be able to return to the Lake past this point.

Chapter 4 Walkthrough

Chapter 5 - Head for the Extraction Point

Crossing the bridge leading toward the abandoned house near the end of Chapter 5 is a point of no return, as you cannot return to the Village past this point in the game.

Chapter 5 Walkthrough

Castle Points of No Return

Chapter 10 - Make Your Way to the Surface

Using the elevator after taking down the Verdugo in Chapter 10 is a point of no return, as you won't be able to return to the Sewers past this point in the game.

Chapter 10 Walkthrough

Chapter 12 - Get to Top of the Clock Tower

After reaching the Clock Tower, riding the lift near the top is a point of no return, as doing so will prevent you from backtracking through the Castle.

Chapter 12 - Go After Ashley

Opening the gate past the Merchant that starts the fight with Ramon Salazar is a point of no return, as finishing the boss fight will force you to ride the boat to the Island, preventing you from returning to the Castle.

Chapter 12 Walkthrough

Island Points of No Return

Chapter 16 - Escape From the Island

Going past the Merchant at the start of the chapter is a point of no return, as the path leading forward leads to the Saddler boss fight, which continues toward the end of the game.

Chapter 16 Walkthrough

The Merchant Will Tell You

The Merchant will tell you when you’re about to cross a point of no return. When he says, "Might want to take care of any leftover errands before going this way. Be a shame to live the rest of your life wondering 'what if?'—am I right?", make sure that you've explored and looted everything beforehand before moving forward.

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