What can you do as a free member?

Member benefits illustration

Create your free account today and unlock all our premium features and tools to enhance your gaming experience.

Member benefits illustration

Create your free account today and save articles to your watchlist and get notified when they're updated with new information.

Member benefits illustration

Create your free account today and save your favorite games for quick access later, synced across all your devices.

Member benefits illustration

By creating a Game8 account and logging in, you'll receive instant notifications when someone replies to your posts.

Comment rating feature illustration

By creating a Game8 account and logging in, you can make use of convenient features in the comments section, such as rating and sorting comments.

Premium archive feature illustration

By creating a Game8 account and logging in, you can access Premium articles that are exclusively available to members.

Site Interface

Guest
Free Member
Article Watchlist
Game Bookmarks
Cross-device Sync
Light/Dark Theme Toggle
User Profiles
Direct Feedback
Comment Rating

Game Tools

Guest
Free Member
Interactive Map Access
Interactive Map Pins
Interactive Map Comments
Interactive Map Pins Cross-Device
Check List
Event Choice Checker
Deck Builder Cross-Device
Message Board Notification
Message Board Cross-Device
Build Planner
Stat Calculator
Diagnostic Tool
Weapon/Armor Wishlist

Want more information?Learn more

Resident Evil 4 Remake (RE4)

Where is the U-3? Missing Boss Fight

10
Add to Watchlist

★ Separate Ways DLC Guide Hub
┗Walkthrough | Weapons | Requests | Unlockables
☆ Ada and Wesker have joined Mercenaries Mode!
★ VR Mode arrives in Winter 2023!
☆ Learn the best ways to speedrun & reach Professional S+!
★ Discover all the Skips you can make in a single playthrough!

U-3 is the missing boss in the Resident Evil 4 Remake's (RE4) main story. Read on to learn where the U-3 could potentially show up in the future!

List of Contents

Where is the U-3?

Missing Boss Fight in the Main Story of RE4 Remake

Unfortunately, U-3 does not appear in the remake's main story, and players won't be able to fight it. In the original, the U-3 was a Boss-type enemy, which Leon encountered in the Island.

Story Walkthrough: All Chapters

Mentioned in the Chronicles of Pursuit 2

RE4 Remake - Chronicles of Pursuit 2

Although U-3 won't appear in the story, it was still mentioned in the Chronicles of Pursuit 2 file you can find in the Castle Throne Room.

The file is a journal written by Isidro Uriarte Talavera, a servant of Ramon Salazar. In it, they write about their process creating the U-3 ("U-III") by fusing the DNA of an insect with that of his human housekeeper.

The current status of the U-3 is unknown by the game's ending.

Might be Included as an Enemy in Mercenaries

The Mercenaries Mode Resident Evil 4 Remake

There's stlll a chance that U-3 will appear as an enemy in the Mercenaries Mode of the game, considering the difficulty of this game mode. Mercenaries Mode will release on April 7, 2023 as a free DLC for all the players who buy any of the Game Editions.

Mercenaries Mode Release Date

Resident Evil 4 Remake (RE4) Related Guides

RE4 Remake - All Bosses

List of All Bosses

All Bosses

Del Lago IconDel Lago El Gigante IconEl Gigante Chainsaw Sisters IconChainsaw Sisters
Bitores Mendez IconMendez Armored Gigante IconArmored El Gigante Verdugo IconVerdugo
Dos Gigantes IconDos Gigantes Jack Krauser IconKrauser Ramon Salazar Mutated IconSalazar
Jack Krauser Mutated IconKrauser (Transformed) Saddler IconSaddler -

Comment

See more comments (10 Comments)

Author

Resident Evil 4 Remake (RE4) Walkthrough Team
This article was created by Game8's elite team of writers and gamers.
    Leave feedback(Login required)
    Please participate in our site
    improvement survey
    12/2025
    Would you assist in
    improving Game8's site?
    ×
    This survey will take about 1 minute.
    Your answers will help us to improve our website.
    We are listening to our users' valuable opinions and discussing how to act on them.
    The information collected through this survey will be used for the purpose of improving our services. In addition, the information will only be disclosed a part of a statistic in a format that will not allow identification of personal information.
    Begin Survey
    Not Now
    ×
    Please rate each item regarding Game8.co's Advertisements.
    Amount of Ads
    Very Dissatisfied
    Somewhat Dissatisfied
    Fine
    Somewhat Satisfied
    Highly Satisfied
    Placement of Ads
    Timing of Ad Display
    Ad Loading Speed
    Safeness of Ads
    Content of Ads
    ×
    Please rate each item regarding Game8.co's Quality of Articles.
    Amount of information
    Very Dissatisfied
    Somewhat Dissatisfied
    Fine
    Somewhat Satisfied
    Highly Satisfied
    Frequency of updates
    Speed of new information
    Accuracy of articles
    Understandibility of articles
    Readability of sentences
    ×
    Please rate each item regarding Game8.co's Usability of the Site.
    Ease of finding information
    Very Dissatisfied
    Somewhat Dissatisfied
    Fine
    Somewhat Satisfied
    Highly Satisfied
    Loading Speed
    Use of Color
    Font Size
    Visibility of Images
    Easy to Understand Layout
    ×
    Please rate each item regarding Game8.co's Message Boards, Comments.
    Ease of Writing
    Very Dissatisfied
    Somewhat Dissatisfied
    Fine
    Somewhat Satisfied
    Highly Satisfied
    Readability
    Ease in Finding Information
    Comment Quality
    Comment Quantity
    Admin Response
    ×
    Please rate each item regarding Game8.co's Site's new design.
    Please rate our site's new design
    Very Dissatisfied
    Somewhat Dissatisfied
    Fine
    Somewhat Satisfied
    Highly Satisfied
    Do you think that the website's design change makes the site easier to use?
    Has the new design made it easier for you to find information on the site?
    Has the new design improved the overall visual appeal of the site?
    How would you rate your overall satisfaction with the new design of the site?
    ×
    How likely are you to recommend Game8 to someone you know?
    Very Unlikely
    0
    1
    2
    3
    4
    5
    6
    7
    8
    9
    10
    Very Likely
    If you have other opinions regarding potential improvement to the website, please share them with us. We would appreciate your honest opinion.
    Note: This is a free response section, so you can proceed without entering anything.
    Note: Please be sure not to enter any kind of personal information into your response.
    ×
    Thank You
    ×
    Thank you for participating in our survey! Your answers will help us to improve the quality of our website and services.
    We hope you continue to make use of Game8.
    Close
    For other opinions or comments, go here.

    Rankings

    Popular Articles
    Message Board
    • We could not find the message board you were looking for.

    Gaming News

    Pokémon Legends Z-A Exclusive Café Donuts Hint At Two Legendaries Returning For Mega Dimensions DLC

    Pokémon Legends Z-A Exclusive Café Donuts Hint At Two Leg...

    Popular Games

    Recommended Games

    All rights reserved

    ©CAPCOM CO., LTD. ALL RIGHTS RESERVED.

    The copyrights of videos of games used in our content and other intellectual property rights belong to the provider of the game.
    The contents we provide on this site were created personally by members of the Game8 editorial department.
    We refuse the right to reuse or repost content taken without our permission such as data or images to other sites.

    Resident Evil 4 Remake (RE4) Walkthrough & Guides Wiki

    Quick Access
    Guide Index

    Separate Ways DLC

    Separate Ways Walkthrough

    Separate Ways Puzzles

    Separate Ways Bosses

    Separate Ways Tips and Tricks

    Mercenaries Mode

    Mercenaries Guides

    Mercenaries Characters

    Mercenaries Stages

    Mercenaries Weapons

    Mercenaries S++ Guides

    Story Walkthrough

    Requests

    Puzzles

    Secrets

    Interactive Map

    Tips and Tricks

    Unlockables

    Speedrun Guides

    Weapon Guides

    Trophy and Challenge Guides

    Settings Guides

    Combat Guides

    Merchant and Money Guides

    Charms and Cases Guides

    Inventory Guides

    Survival Guides

    FAQs

    Story Guides

    Collectibles

    Keys and Locks

    Weapons

    Items

    Bosses

    Enemies and Monsters

    Characters

    Main Characters

    Villains

    Supporting Characters

    Non-Returning Characters

    News and Game Info

    Other Resident Evil Wikis

    Game8 JP Wiki