This is a list of Main Quests in Fallout 4 (FO4). Learn all main quest rewards and unlock conditions, as well as the main quests with points of no return in this guide!
List of Contents
| Main Quest | Info |
|---|---|
| War Never Changes |
Quest Giver: Automatically starts after starting the game.
Rewards: ・XP: No XP Reward ・Vault 111 Jumpsuit |
| Out of Time |
Quest Giver: Automatically starts after War Never Changes.
Rewards: ・XP: 200 ・Pip-Boy ・Codsworth as Companion ・Dogmeat as Companion |
| Jewel of the Commonwealth |
Quest Giver: Mama Murphy
Prerequisite: Talk to Mama Murphy after killing Raiders during When Freedom Calls or go directly to Diamond City. Rewards: ・XP: 150 |
| Unlikely Valentine |
Quest Giver: Ellie Perkins
Prerequisite: Go to Nick Valentine's Detective Agency and talk to Ellie Rewards: ・XP: 200 ・ Caps: 200 ・Worn Fedora ・Faded Trench Coat |
| Getting a Clue |
Quest Giver: Nick Valentine
Prerequisite: Finish Unlikely Valentine then go back to Valentine's Detective Agency to talk to Nick. Rewards: ・XP: 200 ・Nick Valentine as Companion |
| Reunions |
Quest Giver: Dogmeat
Prerequisite: Show Dogmeat the Cigar during Getting a Clue Rewards: ・XP: 250 ・Kellogg's Pistol ・Kellogg's Outfit |
| Dangerous Minds |
Quest Giver: Nick Valentine
Prerequisite: Complete Reunions Main Quest Rewards: ・XP: 372 |
| The Glowing Sea |
Quest Giver: Doctor Amari
Prerequisite: Complete Dangerous Minds Main Quest Rewards: ・XP: 424 |
| Hunter/Hunted |
Quest Giver: Virgil
Prerequisite: Complete The Glowing Sea Main Quest Rewards: ・XP: 423 |
| The Molecular Level |
Quest Giver: Automatically starts after completing Hunter/Hunted Main Quest.
Prerequisite: Complete Hunter/Hunted Main Quest Rewards: ・XP: 484 |
| Institutionalized |
Quest Giver: Automatically starts after completing The Molecular Level Main Quest.
Prerequisite: Complete The Molecular Level Main Quest Rewards: ・XP: 484 |
| Point of No Return Main Quests | |
|---|---|
| Mass Fusion | Underground Undercover |
| Tactical Thinking | Nuclear Option (Minutemen) |
In Act 3 of the Main Quests, you will have to pick one faction to permanently side with to progress to the ending of the main story. This means other factions will become hostile to you, including companions allied with them.
List of Missables and Points of No Return
Mass Fusion is an Institute main faction quest and serves as a point of no return. Completing this quest will ally you with the Institute and progresses you to the end of the main story with this faction's ending.
You will also see the Railroad and Brotherhood of Steel's demise if you decide to complete the game with the Institute. This of course means that Deacon and Paladin Danse will turn on you. However, Danse will not become hostile if you spared him in the Blind Betrayal quest.
All Institute Quests, Location, and Rewards
Underground Undercover is the Railroad faction point of no return, and sees you allying with them to eliminate the Brotherhood of Steel and the Institute.
This will consequently turn Paladin Danse and X6-88 hostile and you will have to kill both of them. However, if you chose to spare Paladin Danse in the Blind Betrayal quest, he will not become aggressive.
Underground Undercover Walkthrough
Tactical Thinking is a Brotherhood of Steel main faction quest, which sees you taking out the leaders of the Railroad. Completing this quest will ally you with them for the rest of the main story, culminating in the Nuclear Option (Brotherhood of Steel) quest, which has you bringing down the Institute.
Finishing the game with the Brotherhood of Steel causes Deacon and X6-88 to become hostile towards you.
The Minutemen's Nuclear Option quest will have you take out the Institute, which also means you have to get rid of X6-88. To add to this, failing to issue an evacuation notice during the quest will cause the Railroad to become hostile.
The Nuclear Option (Minutemen) Walkthrough
| Game8 Fallout 4 Guides | |
|---|---|
 Perk Chart |
 Map |
 Main Quests |
 Side Quests |
 IDs and Item Codes |
 Companions |
 Weapons |
 Armor and Clothing |
 Power Armor |
 Factions |
 Tips and Tricks |
 Materials |
 Achievements |
- |
| Collectibles and Locations | |
|---|---|
| All Bobblehead Locations | All Magazine Locations |
| All Fusion Core Locations | All Chemistry Station Locations |
| Next-Gen Update Added Items | |
| De-Capitalist Helmet | Halloween Decorations |
All Main Quests List
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