Fallout 4 (FO4)

All Main Quests List

Fallout 4 (FO4) Walkthrough Team

Last updated on: May 28, 2024 06:08 AM

Fallout 4 - Main Quests

This is a list of Main Quests in Fallout 4 (FO4). Learn all main quest rewards and unlock conditions, as well as the main quests with points of no return in this guide!

List of Contents

All Main Quests List
Points of No Return
Related Guides

All Main Quests List

All Main Quests in Fallout 4

Main Quest	Info
War Never Changes	Quest Giver: Automatically starts after starting the game. Rewards: ・XP: No XP Reward ・Vault 111 Jumpsuit
Out of Time	Quest Giver: Automatically starts after War Never Changes. Rewards: ・XP: 200 ・Pip-Boy ・Codsworth as Companion ・Dogmeat as Companion
Jewel of the Commonwealth	Quest Giver: Mama Murphy Prerequisite: Talk to Mama Murphy after killing Raiders during When Freedom Calls or go directly to Diamond City. Rewards: ・XP: 150
Unlikely Valentine	Quest Giver: Ellie Perkins Prerequisite: Go to Nick Valentine's Detective Agency and talk to Ellie Rewards: ・XP: 200 ・ Caps: 200 ・Worn Fedora ・Faded Trench Coat
Getting a Clue	Quest Giver: Nick Valentine Prerequisite: Finish Unlikely Valentine then go back to Valentine's Detective Agency to talk to Nick. Rewards: ・XP: 200 ・Nick Valentine as Companion
Reunions	Quest Giver: Dogmeat Prerequisite: Show Dogmeat the Cigar during Getting a Clue Rewards: ・XP: 250 ・Kellogg's Pistol ・Kellogg's Outfit
Dangerous Minds	Quest Giver: Nick Valentine Prerequisite: Complete Reunions Main Quest Rewards: ・XP: 372
The Glowing Sea	Quest Giver: Doctor Amari Prerequisite: Complete Dangerous Minds Main Quest Rewards: ・XP: 424
Hunter/Hunted	Quest Giver: Virgil Prerequisite: Complete The Glowing Sea Main Quest Rewards: ・XP: 423
The Molecular Level	Quest Giver: Automatically starts after completing Hunter/Hunted Main Quest. Prerequisite: Complete Hunter/Hunted Main Quest Rewards: ・XP: 484
Institutionalized	Quest Giver: Automatically starts after completing The Molecular Level Main Quest. Prerequisite: Complete The Molecular Level Main Quest Rewards: ・XP: 484

Main Quests With Points of No Return

Point of No Return Main Quests
Mass Fusion	Underground Undercover
Tactical Thinking	Nuclear Option (Minutemen)

In Act 3 of the Main Quests, you will have to pick one faction to permanently side with to progress to the ending of the main story. This means other factions will become hostile to you, including companions allied with them.

List of Missables and Points of No Return

Mass Fusion (The Institute)

Fallout 4 - Mass Fusion

Mass Fusion is an Institute main faction quest and serves as a point of no return. Completing this quest will ally you with the Institute and progresses you to the end of the main story with this faction's ending.

You will also see the Railroad and Brotherhood of Steel's demise if you decide to complete the game with the Institute. This of course means that Deacon and Paladin Danse will turn on you. However, Danse will not become hostile if you spared him in the Blind Betrayal quest.

All Institute Quests, Location, and Rewards

Underground Undercover (The Railroad)

Fallout 4 - Underground Undercover

Underground Undercover is the Railroad faction point of no return, and sees you allying with them to eliminate the Brotherhood of Steel and the Institute.

This will consequently turn Paladin Danse and X6-88 hostile and you will have to kill both of them. However, if you chose to spare Paladin Danse in the Blind Betrayal quest, he will not become aggressive.

Underground Undercover Walkthrough

Tactical Thinking (Brotherhood of Steel)

Fallout 4 - Tactical Thinking

Tactical Thinking is a Brotherhood of Steel main faction quest, which sees you taking out the leaders of the Railroad. Completing this quest will ally you with them for the rest of the main story, culminating in the Nuclear Option (Brotherhood of Steel) quest, which has you bringing down the Institute.

Finishing the game with the Brotherhood of Steel causes Deacon and X6-88 to become hostile towards you.

Tactical Thinking Walkthrough

The Nuclear Option (Minutemen)

Fallout 4 - Tactical Thinking

The Minutemen's Nuclear Option quest will have you take out the Institute, which also means you have to get rid of X6-88. To add to this, failing to issue an evacuation notice during the quest will cause the Railroad to become hostile.

The Nuclear Option (Minutemen) Walkthrough

Fallout 4 Related Guides

Fallout 4 Wiki

Fallout 4 Walkthrough Wiki

Game8 Fallout 4 Guides
Perk Chart	Map
Main Quests	Side Quests
IDs and Item Codes	Companions
Weapons	Armor and Clothing
Power Armor	Factions
Tips and Tricks	Materials
Achievements	-

Fallout 4 Recommended Guides

Collectibles and Locations
All Bobblehead Locations	All Magazine Locations
All Fusion Core Locations	All Chemistry Station Locations
Next-Gen Update Added Items
De-Capitalist Helmet	Halloween Decorations