Sereniel Best Team and Build
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This is a guide for the best teams and loadout for Sereniel in Chaos Zero Nightmare (CZN). Learn which combatants are best to pair with Sereniel, as well as recommended cards, partners, and equipment.
| Sereniel Guides | ||
|---|---|---|
| Team and Build | Cards and Materials | Banner |
List of Contents
Best Sereniel Build
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 Summary |
 Best Team |
 Best Cards |
 Best Partner |
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 Memory Fragment |
 Equipment |
 Playstyle |
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Build Overview
※ Hover over equipments, memory fragments and cards to see effects
| Character | Partner | Equipment |
|---|---|---|
|
|
 Mutant Predator Spike Mutant Predator Spike When there are 4 or more cards in hand, increase Damage Amount by 30%
Wings of Freedom
Wings of Freedom When hit, +10% Damage Amount (Max 3 stacks)  Emblem of an Exceptional Entity Emblem of an Exceptional Entity +30% Damage Amount. Stress received becomes 0 (1 for each battle) |
| Memory Fragments and Stat Priorities | ||
 Judgment's Flames Set Judgment's Flames Set +50% Damage Amount to Instinct Cards used against Ravaged targets  Executioner's Tool Set Executioner's Tool Set +25% Critical Damage |
1. Instinct Damage % 2. Crit Chance % 3. Crit Damage % 4. Attack |
|
| Cards and Epiphanies | ||
 Homing Laser 4
AP Cost: 0 Type:  Attack ・100% Damage ・ 1 Afterglow ・ On Ravage or at the start of the turn, Move to hand Homing Laser 4
AP Cost: 0 Type: Attack ・100% Damage ・ 1 Afterglow ・ On Ravage or at the start of the turn, Move to hand Homing Laser 4
AP Cost: 0 Type: Attack ・100% Damage ・ 1 Afterglow ・ On Ravage or at the start of the turn, Move to hand Homing Laser 4
AP Cost: 0 Type: Attack ・100% Damage ・ 1 Afterglow ・ On Ravage or at the start of the turn, Move to hand  Plasma Missile 3
AP Cost: 1 Type: Attack ・120% Damage ・ 2 Instinct Weakness ・ +60% Damage Amount to Homing Laser for 1 turn(s)  Shining Core 3
AP Cost: 1 Type: Tags: Unique, Initiation Upgrade ・Create 2 Homing Laser L ・ On Ravage, create 2 Homing Laser L  Cobalt Light 4
AP Cost: 1 Type: Attack ・120% Damage to random enemies ・ Add 1 Hit for each Homing Laser in hand  Pale Shooting Star 0
AP Cost: 2 Type: Attack ・150% Damage ・ Activate 3 Homing Laser cards in Draw Pile and Graveyard |
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Sereniel's best build focuses on consistently getting at least 4 Homing Lasers every turn and getting 6 or more Homing Lasers when ravaging enemies. This build makes sure that your deck does not get populated by Homing Lasers and ensures that you do not need to keep track of the exhaust tags of your Homing Laser L.
She is best suited with the 4/2 set consisting of Judgment's Flames and Executioner's Tool to enhance the damage of her Homing Lasers. She benefits more with these sets as it is additive damage to her Homing Lasers which is the best option as it has low base damage multipliers.
Her favored chaos zone is Laboratory 0 to get her best equipment such as Mutant Predator Spike for 30% multiplicative damage buff if there are 4 more cards in your hand. Wings of Freedom to get increasing 10% multiplicative damage buff after getting hit for a total of 3 times and Emblem of an Exceptional Entity for 30% additive damage buff to all of Sereniel's attacks. Other chaos zones cannot offer all equipment slots that buffs damage hence why Laboratory 0 is the best option to get.
| Date | Changes |
|---|---|
| 12-24-2025 | ・Initial Sereniel build |
Sereniel Best Team
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|---|---|---|---|---|---|---|---|---|---|---|---|
| Summary |
Best Team |
Best Cards |
Best Partner |
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| Memory Fragment |
Equipment |
Playstyle |
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| Sub-DPS | Support |
|---|---|
 Rei
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 Cassius
|
Sereniel's best team is Rei and Cassius. Rei can additively buff Sereniel's 0-cost cards and occassionally her multi-hit cards to deal even more damage. She can also provide constant minor heals and provide Morale buffs that can further boost Sereniel's damage.
Cassius on the other hand, helps with providing more morale buffs with his quest completion or his Straight quest card. He can also search specific cards to help you consistently fish for Sereniel's multi-hit attack or her Instinct Weakness debuff. He can also help heal the party and provide defensive buffs such as Fortitude.
Alternative Team Members
| Character | Explanation |
|---|---|
 Veronica
|
Veronica can replace Rei or Cassius as another Support especially if you need more draw for Sereniel that your Cassius or Rei cannot provide at the moment. |
 Hugo
|
Hugo can replace Rei or Cassius as a Sub-DPS with his Commence the Hunt stacks to help follow-up attacks with Sereniel's Homing Lasers especially if you get the skill card epiphany of her Shining Core. |
 Nia
|
Nia can replace Rei or Cassius as another Support if you are in need of more AP and draw as she can enable the Eternal Hunger combo at the cost of losing out damage for Sereniel. |
 Selena
|
Selena can replace Rei or Cassius as another Sub-DPS as she is the only character capable of restoring the tenacity bar of an enemy. She is especially great if you are aiming for a more one-turn kill builds. |
 Mika
|
Mika can replace Rei or Cassius as another Support if you are in need of survivability and wants more AP recovery to use Sereniel's cards. |
Sereniel Best Cards
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|---|---|---|---|---|---|---|---|---|---|---|---|
| Summary |
Best Team |
Best Cards |
Best Partner |
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| Memory Fragment |
Equipment |
Playstyle |
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| Card | Explanation |
|---|---|
|
Homing Laser
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AP Cost: 0
Type:
Attack
・100% Damage ・ 1 Afterglow ・ On Ravage or at the start of the turn, Move to hand |
|
Plasma Missile
|
AP Cost: 1
Type:
Attack
・120% Damage ・ 2 Instinct Weakness ・ +60% Damage Amount to Homing Laser for 1 turn(s) |
|
Shining Core
|
AP Cost: 1
Type:
Upgrade
Tags: Unique, Initiation ・Create 2 Homing Laser L ・ On Ravage, create 2 Homing Laser L |
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Cobalt Light
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AP Cost: 1
Type:
Attack
・120% Damage to random enemies ・ Add 1 Hit for each Homing Laser in hand |
Sereniel can be built many ways but her most consistent and reliable build consists of Homing Laser with the epiphany that enables it to go to your hand at the start of the turn and when the enemy is ravaged. You lose damage and a stack of afterglow buff but at the cost of always getting at least 4 Homing Laser in your hand every turn start without needing to worry about the Exhaust tag. This should be your prime target for duplication and divine epiphanies.
Her choice of Plasma Missile will always be the epiphany that inflicts 2 stacks of Instinct Weakness to an enemy at the cost of losing tenacity damage. This is a fine exchange as this will increase the overall damage and tenacity damage of all your attacks for 2 turns even if the attribute is not Instinct. This makes her perfect to contents that are not Instinct focus.
Shining Core should have the epiphany that makes it an upgrade card with the Initiation tag as it will always give you 2 Homing Laser L after ravaging an enemy. This makes it so you can play at least 10 Homing Lasers every turn.
Cobalt Light must be the epiphany that increases its hit count the more Homing Lasers you have in hand. Since we have the Shining Core upgrade card epiphany, this ensures that Cobalt Light will always have at least 6 hits making it better than the rest of the epiphanies.
Essential Team Cards and Epiphanies
| Cassius Card | Explanation |
|---|---|
 Pop Eyed Popper
|
AP Cost: 0
Type:
Upgrade
・From 4 Quests, choose 1 to begin |
 Devil Dice
|
AP Cost: 0
Type:
Attack
・Draw 1 ・80% Damage to all enemies equal to that card's cost |
 Shuffle
|
AP Cost: 1
Type:
 Skill
Tags: Exhaust 2 ・Discard all cards in hand ・Draw as many as the number discarded |
 Dice Trick
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AP Cost: 2
Type:
Upgrade
・On Quest completion, create 1 Quest Card(s) |
| Rei Card | Explanation |
 Resonating Darkness
|
AP Cost: 1
Type:
Upgrade
Tags: Unique ・+40% Damage of cards with cost 1 or below |
 Snack Time
|
AP Cost: 0
Type:
Skill
Tags: Retain, Exhaust ・Heal 150% ・Draw 2 |
 Dark Condensation
|
AP Cost: 1
Type:
Skill
・Choose 1 Attack Card(s) in hand, +150% Damage for 1 turn |
Cassius' important cards will always be the Triple-0 Dice Trick combo to make sure that he can give the party at least 2-3 Morale buffs every turn. However, if he can generate a lot of quest cards, it will interfere with Sereniel's Homing Lasers from coming back to your hand so make sure to use his quest cards as soon as possible to free up your hand. He can also get Cobalt Light with his Joker if you wish.
Rei on the other hand, should always have the epiphany for her Resonating Darkness that buffs the 0-AP cards too so that Sereniel's Homing Lasers can deal more damage as that is her main source of damage. You can choose any epiphany for Snack Time but the draw 2 epiphany makes it more consistent for early turns. Her Dark Condensation is great for Cobalt Strike only as it can massively increase its damage output.
Sereniel Best Partner
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|---|---|---|---|---|---|---|---|---|---|---|---|
| Summary |
Best Team |
Best Cards |
Best Partner |
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| Memory Fragment |
Equipment |
Playstyle |
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| Partner | Details |
|---|---|
 Peko
|
Passive Effect: Overclock Beacon - The assigned combatant's Attack is increased by 8%. When the assigned Combatant's card moves from Graveyard to hand, hain 1 [Repairs Complete!]. [Repairs Complete] +10% Damage to Attack Cards of this unit during this battle (max 3 stacks). Increase Damage of the assigned Combatant's Attack Cards that are used against Ravaged targets by 15%. Ego Skill: Peko's Multi-Purpose Kit - When an ally inflicts Ravage, 1 Overclock to the assigned Combatant (1 time per turn). Overclock: +25% Critical Chance for 1 turn. |
Sereniel's best partner is Peko as she has the passive ability to increase the damage of her cards once she has moved cards from the graveyard three times and will last for the entire fight. She also has multiplicative damage buff against enemies that are in ravaged state. She also has the ego skill that will give Sereniel a critical chance buff after ravaging an enemy once per turn that also lasts for the entire fight.
Alternative Budget Partner
| Partner | Details |
|---|---|
 Yuri
|
The only budget hunter partner that can rival Peko is a max manifest ego Yuri as she has an innate 16% increase to Sereniel's base attack and a permanent 16% damage increase to all of her attacks once you shuffle your deck in a fight. |
Yuri vs Peko Damage Comparison
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| Yuri (Left) vs Peko (Right) Damage Against Unravaged Enemies |
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| Yuri (Left) vs Peko (Right) Damage Against Ravaged Enemies |
This test excludes damage buffs from the potentials, manifest ego, equipment and partners of the party members. The test also has both partner passives activated to compare the highest possible damage output they can provide for Sereniel.
Sereniel Best Memory Fragments
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|---|---|---|---|---|---|---|---|---|---|---|---|
| Summary |
Best Team |
Best Cards |
Best Partner |
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| Memory Fragment |
Equipment |
Playstyle |
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Judgment's Flames Set Judgment's Flames Set +50% Damage Amount to Instinct Cards used against Ravaged targets |
Executioner's Tool Set Executioner's Tool Set +25% Critical Damage |
Sereniel's best memory fragment is Judgment's Flames and Executioner's Tool. The first set gives all of her cards +50% additive damage buff which is great for her as most of her attacks consists of low damage multipliers. Sereniel builds off critical chance therefore it is best for her to also increase her critical damage.
Stat Priority
| Main Stats | Recommended Substats |
|---|---|
|
Ideal: Critical Chance % Desire: Instinct Damage % Imagination: Attack % |
・Critical Chance % (At least 60%) ・Critical Damage % ・Attack ・Attack % |
The main stat and sub stats Sereniel needs are Instinct Damage, Critical Chance, Critical Damage and Attack. Her last potential node needs at least 60% critical chance so aim for that if you can to get more damage boost to her Homing Lasers.
Sereniel Best Equipment
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|---|---|---|---|---|---|---|---|---|---|---|---|
| Summary |
Best Team |
Best Cards |
Best Partner |
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| Memory Fragment |
Equipment |
Playstyle |
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| Weapon | Armor | Accessory |
|---|---|---|
|
Mutant Predator Spike Mutant Predator Spike When there are 4 or more cards in hand, increase Damage Amount by 30% |
Wings of Freedom Wings of Freedom When hit, +10% Damage Amount (Max 3 stacks) |
Emblem of an Exceptional Entity Emblem of an Exceptional Entity +30% Damage Amount. Stress received becomes 0 (1 for each battle) |
Sereniel's best equipment can only be found in Laboratory 0 with Mutant Predator Spike giving her 30% more damage for all of her attacks as long as you have 4 or more cards in hand. Wings of Freedom for 10% more multiplicative damage each time your team gets hit up to 3 times.
Emblem of an Exceptional Entity is great for her as it has +30% additive damage to all of her attacks making her Homing Missiles much more potent.
Foggy Crystal Ball For More 0-Cost Damage
 Foggy Crystal Ball Foggy Crystal Ball +40% Damage for Attack cards with Cost 0 |
If you have the chance to get this equipment and you did not get Mutant Predator Spike, you can use Foggy Crystal Ball instead as it multiplicatively increases the damage of her 0-AP cards by 40% at the cost of losing damage to her Plasma Missle, Cobalt Light and Pale Shooting Star.
Alternative Budget Equipment
| Weapon | Armor | Accessory |
|---|---|---|
 Obsidian Sword Obsidian Sword Increase damage amount by 12% |
 Incomplete Carapace Incomplete Carapace At the end of the turn, if you have 3 or more Cards in hand, +140% Fixed Shield |
 Amorphous Cube Amorphous Cube +25% Damage |
If you aren't able to get the best, you can settle for these equipment that some can be found in any chaos zones inside shops. Obsidian Sword to boost the overall damage of all her attacks. Incomplete Carapace for shield if you have 5 or more cards in hand at the end of turn which is easily achievable by her but can only be found in Laboratory 0 and Amorphous Cube gives a permanent +25% damage to all her attacks.
Sereniel Build Tips and Playstyle
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| Summary |
Best Team |
Best Cards |
Best Partner |
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| Memory Fragment |
Equipment |
Playstyle |
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Homing Laser and Cobalt Light Combo
Sereniel's best combo revolves around setting up for the right turn to unleash Cobalt Light after obtaining all the Homing Lasers when the enemy is ravaged. Here's how to do it:
- Make sure you have Cobalt Light in hand and Shining Core activated.
- (Optional) Use Plasma Missile to inflict Instinct Weakness to the enemy to deal more damage.
- Use your Homing Laser to Ravage the enemy. Stop using it once the enemy is ravaged.
- You should have at least 6 Homing Laser in hand.
- (Optional) Use Predator's Blade or Dark Condensation to buff Cobalt Light only if you have spare AP.
- Use Cobalt Light to deal high single-target damage or across multiple enemies randomly.
- If the enemy is still not dead, use the remaining Homing Lasers to deal more damage.
Multi-Hit Attacks Uses Only 1 Stack of Afterglow Against One Ravaged Enemy
As shown in the video above, it only uses 1 stack of Afterglow to deal the same damage across multiple hits only if the enemy is ravaged and only one target.
Use Your Homing Lasers First
Sereniel's exclusive buff called Afterglow enables her attacks to deal 1 tenacity damage and +50% additive damage regardless of the attribute of the enemy. Her only source of this buff comes from her Homing Lasers, so make sure to always play it first before using her other cards that doesn't
Multi-Hit Attacks Uses 1 Stack of Afterglow Each Per Tenacity Bar
If you use a multi-hit attack such as Cobalt Light, it will consume afterglow stacks per tenacity each for each hit. This can also apply to multiple enemies where the attack can jump to another target with tenacity bar left and it will consume it.
Clear Your Hand Before Ravaging an Enemy
All of Sereniel's Homing Laser will try to go back to your hand after you ravage an enemy. If you built her with cards that generate Homing Lasers, make sure to free your hand of cards to get the most amount of Homing Laser as you can only hold 10 cards.
Pale Shooting Star Does Not Include Exhaust Pile
Pale Shooting Star only activates Homing Lasers from the discard pile, draw pile and used card pile but not the exhaust pile. Make sure to check if you have enough Homing Lasers to activate when you are about to use it.
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