NEO: The World Ends with You (NEO TWEWY)

How to Beat Plague Nemopilema | Boss Fight Guide

Plague Nemopilema Banner.png

This is a guide to beating Plague Nemopilema in NEO: The World Ends with You (NEO TWEWY). Learn about Plague Nemopilema's attack patterns, weaknesses, and tips and strategies for defeating them.

Plague Nemopilema Basic Information


No. 065 Noise Group NEO TWEWY Noisepedia - Plague Nemopilema Noise Type.png
NEO TWEWY Noisepedia - Plague Nemopilema.png
The king of the jelly-fish like Plague Noise, created by Shiba himself. Wobbles its flexible frame to clone itself and create its own unstoppable army.
Location W3D4 (Story)


HP 43000
PP 111
EXP. 200
NEO TWEWY - Fire Icon.png Fire

The data shown is set on Normal Diffculty.

Drop Rates

Easy Drop: Electric Manicure
Rate: 2.00%
Normal Drop: RaiJin Surge
Rate: 2.00%
Hard Drop: RaiJin Surge
Rate: 2.00%
Ultimate Drop: 100,000 Yen
Rate: 0.05%

The data shown is on 1x Drop Rate.

Plague Nemopilema Attacks and Abilities

Electric Trip Wire

Electric Trip Wire2.png

Plague Nemopilema, along with its smaller clones, can make an electric trip wire.

Getting caught in it will damage your team's HP and deplete your groove quickly. Plague Nemopilema and its clones will get rid of the electric trip wire after a few seconds.

Spin Attack

Spin Attack.png

Plague Nemopilema and its clones can do a spin attack that damages anything nearby. Just like electric trip wire, this ability can also deplete your groove in a matter of seconds.



Lastly, Plague Nemopilema can create smaller clones of itself. These clones cannot make other clones but they can do a spin attack and electric trip wire.

Best Pins for Plague Nemopilema

Fire in the Belly IconFire in the Belly
All Burned Out IconAll Burned Out

Plague Nemopilema is weak to fire so it's better to equip pins with this affinity.

All Burned Out is a great contender for this fight because it can deal lots of damage to Plague Nemopilema. It is also available pretty early in the game.

Fire in the Belly, on the other hand, can deal continuous damage to multiple enemies at the same time. This is very helpful when you're dealing with Plague Nemopilema's clones.

Tips & Strategies for Beating Plague Nemopilema

Strategy Checklist
CheckmarkTake down Plague Nemopilema first

CheckmarkFight from a safe distance

Take Down Plague Nemopilema First

Plague Nemopilema's clones can be a handful if there are too many of them. With this in mind, it's much better to take down Plague Nemopilema first to make sure that it can't clone itself anymore.

Fight From a Safe Distance

Plague Nemopilema can counter your melee pins with a spin attack so it's much better to fight it from a distance. This doesn't mean that you shouldn't use melee pins though. They're still very useful. Just be cautious when using them.

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1 Anonymousalmost 3 years

Question. I see that the ultimate drop for this one is unknown. Does someone know what it is?


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