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Honkai: Star Rail

Natasha Quest Guide - Origin of the Medicine

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Honkai Star Rail - Origin of the Medicine

Origin of the Medicine is the first Companion Mission for Natasha in Honkai: Star Rail. Check out how to unlock this mission, its walkthrough, rewards for completion, and all choices in this guide!

All Natasha Companion Missions
Origin of the Medicine Blizzard Immunity

List of Contents

Origin of the Medicine Information

Mission Type Companion Mission
Location Jarilo-VI, Boulder Town
Required Level 20

Part 1 of Natasha's Companion Mission

Origin of the Medicine is the first part of Natasha's Companion Mission. This mission will have us investigate the medicine Dr. Vache, Natasha's brother, has created.

After you complete all of her Companion Missions, Natasha will appear on the Astral Express to visit!

How to Unlock Origin of the Medicine

Unlock Requirements

How to Unlock Reach Trailblaze Level 20 or above
Complete Trial of the Equilibrium: Part 1

Respond to Oleg's Message After Returning to Boulder Town

Honkai Star Rail - How to Unlock Origin of Medicine

Oleg will message players once they return to Boulder Town after completing the Trial of the Equilibrium: Part 1. Respond to his message to get Natasha's companion quest, Origin of the Medicine

Origin of the Medicine Walkthrough

Mission Walkthrough

Quest Walkthrough
1 To begin, head to Natasha's Clinic in Boulder Town and speak to Natasha.
2 Talk to first patient who skipped treatment. They can be found standing in front of the Fight Club building.
3 After convincing the first patient, visit the second patient who skipped their follow-up visit. They can be found on the road from the Fight Club to the Goethe Grand Hotel.
4 After convincing the second patient, visit the third patient who skipped their follow-up visit. They can be found at the foot of the stairs that lead up to the Boulder Town Food Stall.
5 Convince him that you do not approve of Natasha. Tell him you want Dr. Vache's miracle cure and he will tell you the location of the society that sells it.
6 Now you have the option either tell Natasha about the wonder medicine or investigate it by yourself.
・Tell Natasha... (Go to Step 8)
 ・Investigate the Medicine (Go to Step 7)
7 If you decided to investigate the wonder medicine, make your way to Rivet Town. Despite acting like a buyer, the Vargrants will identify you as a threat and turn you away.
8 Return to Natasha and tell her about the wonder medicine.
9 She will ask you to speak to 3 patients affected by the wonder medicine. Go to each one (marked in your map) to find out more about the medicine.
10 Go back to Natasha and speak to her. After the conversation ends, go to Rivet Town and confront the medicine peddlers.
11 Defeat the 2 Vagrants and 2 Automaton Beetles guarding the wonder medicine. When the dust of battle settles, watch Natasha chase out the medicine peddlers.
12 With the suppliers stopped, head back to Natasha's clinic. Watch the cutscene that plays out.
13 Speak to Natasha to complete Origin of the Medicine.

Tell Natasha or Seek Out the Wonder Medicine?

Telling Natasha Saves You From a Step During the Mission

The only difference between telling Natasha first and investigating by yourself is that you add a step if you decide not to tell Natasha first. Telling Natasha about the wonder medicine first will progress the quest faster since you get to skip the step that has you go to Rivet Town to investigate.

Origin of the Medicine Rewards

Mission Rewards
Star Rail - Trailblaze EXP Item Trailblaze EXP x350 Star Rail - Stellar Jade Item Stellar Jade x60 Star Rail - Adventure Log Item Adventure Log x6
Star Rail - Shield Item Shield x200 Star Rail - Credit Item Credit x20000

Honkai: Star Rail Related Guides

All Missions and Mission Types

List of All Companion Missions

Character Companion Missions
Star Rail - AstaAsta ・You Already Know Me
Star Rail - ArlanArlan ・An Unexpected Turn of Events
Star Rail - NatashaNatasha ・Origin of the Medicine
・Blizzard Immunity
Star Rail - HookHook ・Old Foreman's Treasure
・Hook's Treasure
・Hook's Gift
Star Rail - ClaraClara ・Rarely Affectionate (Part 1)
・Rarely Affectionate (Part 2)
Star Rail - GepardGepard Star Rail - ServalServal ・Time Express
・Only a Child
Star Rail - Silver WolfSilver Wolf ・Punklorde Mentality
Star Rail - LuochaLuocha ・A Knight Stranger
Star Rail - YanqingYanqing ・Frosty Blade's Trial
Star Rail - BailuBailu ・Evanesce Like the Morning Dew
・Tale of Woe
Star Rail - YukongYukong ・For I Have Touched the Sky
Star Rail - KafkaKafka ・Letter from a Strange Woman
Star Rail - Fu XuanFu Xuan Star Rail - March 7thMarch 7th ・Total Recall
Star Rail - PelaPela Star Rail - LynxLynx ・Farther Than The Snowplains
Star Rail - Imbibitor LunaeImbibitor Lunae ・The Dragon Returns Home
Star Rail - LukaLuka ・Mo Cuishle
Star Rail - JingliuJingliu ・Clouds Leave No Trace
Star Rail - ArgentiArgenti ・Night of Universal Hallucinations
Star Rail - Black SwanBlack Swan Star Rail - SparkleSparkle ・Masquerade Duet
Star Rail - YunliYunli ・Swords to Plowshares

All Companion Missions

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