Scientific Methods is a Side Mission in Dead Space Remake (2023) focusing on Nicole's investigations about the origin of the Necromorph outbreak aboard the Ishimura. Read on for a detailed walkthrough, tips for completion, unlock conditions, and more!

How to Unlock Scientific Methods

Find Nicole's Log in Main Lab

Nicole Brennan is a Senior Medical Officer aboard the USG Ishimura. Her office is located inside the Main Lab, accessible as early as Chapter 2. Interact with her audio log inside her office to begin this side mission.

Chapter 2: Intensive Care Walkthrough

Scientific Methods Walkthrough

Scientific Methods Summary

Scientific Methods Objectives
Investigate Emergency Room Follow Nicole's Hologram Find Autopsy Location in Engineering Find Kyne's Hideout in Mining Deck Investigate Mercer's Quarters

Scientific Methods Detailed Walkthrough

	Objectives
1	Investigate the Emergency Room. When you arrive in the Emergency Room, interact with one of the beds and a hologram recording of Nicole will play out.
2	Follow Nicole's Hologram. Nicole's hologram will seem to disappear into a wall in the ER. Grab the Power Cell and reroute power to the Shower Rooms to reveal the door. Use Kinesis to open the door and find Nicole's Audio Log inside.
3	Find the Autopsy Location in Engineering. The autopsy location will be in the Calibration Room in the Machine Shop. From the Security Station in Engineering, go to the Prep Room and down to the Machine Shop. Then when facing the door to the Refueling Stations, go in the direction to your right and find the Calibration Room just by the Bench.
4	Find Kyne's Hideout in Mining Deck. Reach Deck D - Maintenance in the Mining Deck. Go to Secure Storage. Reach for the Circuit Breaker at the end of the hall. Reroute power to Storage 02 to reveal Kyne's Hideout. Interact with the audio log in the room to continue.
5	Investigate Mercer's Quarters. This objective will be locked until you reach Chapter 10 and have access to the Crew Deck. Once you have the Crew Deck Key, you will now be able to reach Mercer's Quarters. From the Crew Deck Tram Station, head straight to the Crew Deck and down to the Common Area. Go to the Zero-G Gym and get the Power Cell from inside the Zero-G Basketball Room. Power Up the Elevator and Crew Deck Key from the corpses at the far side of the room. Once you have the card, go back to the Common Area and take the elevator to the Central Nexus Floor 1. After the confrontation with Mercer and Temple, escape the Hunter and follow the chapter objectives until it prompts you to go to the Deluxe Quarters. Once there, go inside the Guest Quarters. Once you finish the recording of Isaac and Nicole speaking to each other, go the adjacent room and interact with the terminal.

Scientific Methods Completion Reward

Whole Again Trophy

Silver G:30	Whole Again
	Pursue Nicole's investigation. ►Scientific Methods Side Mission Guide

Completing the Scientific Methods Side Mission awards you with the Whole Again Achievement! This trophy is semi-missable in the sense that until you reach that point-of-no-return in Chapter 11, you will have the chance to complete it in your playthrough.

List of All Trophies and Achievements

Dead Space Remake Related Guides

Full Story Walkthrough: All Chapters

Main Missions

All Story Chapters
New Arrivals (Chapter 1)	Intensive Care (Chapter 2)
Course Correction (Chapter 3)	Obliteration Imminent (Chapter 4)
Lethal Devotion (Chapter 5)	Environmental Hazard (Chapter 6)
Into the Void (Chapter 7)	Search and Rescue (Chapter 8)
Dead on Arrival (Chapter 9)	End of Days (Chapter 10)
Alternate Solutions (Chapter 11)	Dead Space (Chapter 12)

Side Missions

Dead Space Remake Side Missions
Scientific Methods	You Are Not Authorized	Premeditated Malpractice