Lethal Devotion is the fifth chapter of Dead Space Remake (2023)'s main story. Read on for a detailed walkthrough, list of rewards, tips for completion, Lethal Devotion Schematic Locations, as well as other strategies!

Chapter 5: Lethal Devotion Collectible Locations

Interactive Collectibles Map

Weapon and Upgrade Locations

Weapon/Upgrade	Location
Line Gun	Found inside the Emergency Equipment Storage at the Medical Deck.
Pulse Rifle	Dropped by a dying security officer once you reach the Tram Station in the Medical Deck.
Kinesis Module	Found on top of a crate as you enter the Medical Cargo Depot at the start of Chapter 2.
Stasis Pack	Schematic found in the Main Lab Changing Room in Chapter 2, after clearing the quarantine.
Pulse Rounds	Schematic found inside the Coolant Pipelines room in Chapter 2, to your immediate left after leaving the oxygenless area.
Line Racks	Schematic found inside the Dr. B. Warwick - CPO room in the hallway leading to Zero-G Therapy in Chapter 5. Requires Security Clearance Level 2.
Cartridge Rack	Found inside the Ishimura Clinic in Chapter 2, on top of the seats on the left side of the room.
Portable Heliotron	Found inside the Bioprosthetics Locker Room past the Main Lab Changing Room in Medical. Requires Security Clearance Level 3.
Photon Energizer	Found inside the Lab Storage room near Cryogenics in Medical. Requires Security Clearance Level 3.
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Log Locations

Log	Event Trigger
Calculated Risks	Found on top of a surgical bed inside the Medical Deck Observation Room.
They Defy Death Itself	Found in a bathroom cubicle at the lower level of the Medical Deck’s Main Lab.
Marker Discovery	Found on top of a table inside Dr. T. Kyne’s Office.
Nicole's Log	Found on the desk inside Dr. Nicole Brennan’s Office in the Main Lab of the Medical Deck.
Anonymized Transcript	Found on a shelf inside Dr. Nicole Brennan’s Office in the Main Lab of the Medical Deck.
Vital Personnel	Found on a desk inside the Biological Prosthetics Center of the Medical Deck.
Patient Observations	Found on one of the medical beds inside the Emergency Room.
Nicole's Study	Found on an operating table hidden behind the shower in the Emergency Room.
Rats in the Walls	Found by interacting with the mail terminal just beside the door to the Intensive Care Unit in ER Hallway B.
Colony's Problems	Found at the end of ER Hallway B, just beside the O2 station.
Autopsy Report	Found on a desk inside the Morgue.
Patient Harris	Found on a desk inside the Consultation Room of the Imaging Diagnostics Room.
Mercer's Volunteer	Found on a desk inside the Medical Deck Observation Room.
Dr. Kyne's Dementia	Found in the ER Hallway A, just in front of the room that needs a Leve 2 Security Clearance.
Sterile Instruments	Found at the end of ER Hallway B, on a gurney near the O2 Station.
Harris's Choice	Found on a desk in the Intensive Care Unit.
Mercer's Journal	Found inside Dr. Challus Mercer’s Office.
A Tissue Sample	Triggers after you pick up the Hunter’s tissue sample in Cryogenics.
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All Log Locations

Chapter 5: Lethal Devotion Walkthrough

Lethal Devotion Summary

Lethal Devotion Detailed Walkthrough

	Objectives
1	Return to the Medical Deck. After receiving a video log of Nicole, Isaac will prompt to return to the Medical Deck and search for Nicole. Run towards the elevator and get back down to the Main Atrium, then hurry over to the Bridge Tram Station and plot a course to Medical.
2	Locate the Source of the Broadcast. Go straight to the Security Station where you'll have a conversation with Dr. Challus Mercer. After the conversation ends, go to Imaging Diagnostics Wing. Take the elevator to the Main Lab. Shoot the Yellow Sacs to burst a section of the Necromorph mass. Pass through the door to Zero-G Therapy but take a left towards the Cryogenics Lab. Take the eleveator down and go into the Chemical Lab to stop the broadcast.
3	Escape the Creature. After stopping the broadcast, Dr. Mercer will hit you with Stasis and you will be forced to listen to him for a while. After which he will set his creation, the Hunter, a regenerating Necromorph, upon you. This creature cannot be killed by normal means. Your only chance is to cast stasis on it or shoot its limbs as you try to get away. Once Kendra has the doors unlocked, bolt straight out. Go to Imaging Diagnostic directly from the Chemical Lab and straight to the Security Station.
4	Lift the Lockdown. Rush straight to the Emergency Room. Multiple Necromorphs, including the Hunter, will spawn there so be prepared for a fight. Use the Stasis bombs when they are in close proximity to one another for better crowd control. When you can, Kinesis-grab the Power Cell to open the door to ER Hallway A and head to the ICU. A Guardian will be posted by the ICU, take care of it before approaching the ICU. Head inside the ICU towards the Morgue, but take the door to the right of the Morgue elevator to Dr. Mercer's office and lift the lockdown from there.
5	Stop the Poison Gas. When you get out of Mercer's office, a gas toxin will be released into the atmosphere. You have to run back towards the Security Station to bring back life support. There are O2 recharge stations but this will mostly be a simple run towards the Security Station, it is not recommended to fight against any enemy you can avoid easily.
6	Acquire the Liquid Nitrogen. You'll have to go back to Imaging Diagnostic Wing and to the Cryogenics Lab. The Liquid Nitrogen you seek is in the Cryogenic Chamber. When you pick up the item, Dr. Mercer will interrupt once more to deliver his speech, and afterwards he will send his creation to finish you completely.
7	Defeat the Hunter. Much like the original game, your best bet against the Hunter in this situation is to make the most of your environment. Use stasis on the Hunter, while you shoot off its limbs. As it tries to regenerate from within the cryogenic chamber, run to the console to activate the Cryo Freeze process. Afterwards, pick up the Tissue Sample and return to the Medical Tram Station. ►Premeditated Malpractice Side Mission Guide

Chapter 5: Lethal Devotion Tips and Strategies

Do Not Approach Guardians

Guardians usually appear attached to walls or hallways, and fire ranged Necromorphs that will use a tentacle to attack you. Getting too close to a Guardian is certain death. Instead, use your Kinesis Module to throw explosives at its stomach to kill it.

How to Beat Guardians

Do Not Engage the Hunter

Once you reach the Chemical Research Lab, this will be the first time you face the Hunter. It may look like a Slasher on steroids, but this is a Necromorph like no other. It has regenerative abilities so you cannot kill it. Shooting off its limbs only slows it down momentarily. Your only option is to hit it with your Stasis Module to slow its regeneration process, and run while you can.

Use Stasis to Conserve Ammo

Once the Life Support System is compromised, you will be prompted to run to the Security Station to turn it back on. You will have to go back through Medical and face the Hunter along with two Pregnants. Don't bother shooting the Necromorphs as it will only consume time you don't have. Instead use stasis to slow them down and make your way to the other side of the room.

Lure the Hunter into the Cryo Chamber

After dealing with the other Necromorphs, lure the Hunter into the Cryo Chamber and begin dismembering its legs. When it goes down, use Kinesis to slow it down as you race to the control panel and jumpstart the Cryo Chamber.

Chapter 5: Lethal Devotion Enemies Encountered

List of Necromorphs
Guardian	Weak Spots: Tentacles Weaknesses: Explosives
Hunter	Weak Spots: None Specific Weaknesses: Stasis
Lurker	Weak Spots: Tentacles Weaknesses: None
Pregnants	Weak Spots: Limbs Weaknesses: Stasis
Swarmers	Weak Spots: None Specific Weaknesses: Stasis, Explosives, Fire

Dead Space Remake Related Guides

Full Story Walkthrough: All Chapters

Main Missions

All Story Chapters
New Arrivals (Chapter 1)	Intensive Care (Chapter 2)
Course Correction (Chapter 3)	Obliteration Imminent (Chapter 4)
Lethal Devotion (Chapter 5)	Environmental Hazard (Chapter 6)
Into the Void (Chapter 7)	Search and Rescue (Chapter 8)
Dead on Arrival (Chapter 9)	End of Days (Chapter 10)
Alternate Solutions (Chapter 11)	Dead Space (Chapter 12)