Knowing about best skills to use in the 2022 reboot of Saints Row (Saints Row 5) will carry you far against your rival gangs. Read on to learn more about the best skills and skill loadouts you can use from the early game until the end game!

Saints Row (2022) Best Guides
Best Weapons	Best Vehicles
Best Perks	Best Skills

Endgame Skill Loadout (Lv. 20+)

All-Rounded Boss

Lv	Skill	Description
2	Pineapple Express	Grab an enemy, drop a grenade down their pants, and throw them.
6	Tough Mother	Gain a temporary health boost to absorb damage from enemies and negate staggers.
17	Intercession	Call in some Saints to help you fight.
19	D4th Blossom	Spin around and fire bullets in every direction.

Skill Loadout Merits

The endgame gives us all the tools to become a bonafied boss of the Saints! This loadout strikes a strong balance between damage and survivability and has been tested at the endgame under Boss Difficulty.

Pineapple Express is one of the best skills in the early game because of its damage output and AoE range. The skill can also be used on Tough Enemies with their armor on, making it a great mini-boss killer in dire scenarios.

Tough Mother is retained to ensure our survivability during fire fights. You'll have plenty of Flow points at the level 20, allowing you to start fights off with this skill to gain an extra layer of HP off the bat! Take note that this skill can only be reused once your temporary HP is completely depleted.

Intercession is a great utility skill to have at the endgame. You can summon two Saints NPCs from almost anywhere that can help you out in battle. The damage from these NPCs are decent enough at the highest difficulty, but the biggest strength of this skill is the ability for the NPCs to soak up a ton of damage. Take note that the AI may bug out in certain scenarios, but they can still serve as meat shields that draw aggro away from you.

D4th Blossom let's you eliminate groups of enemies within close range. The damage is high enough to destroy common vehicles as well, allowing you to set off chain explosions when positioned carefully. Use this in tandem with Tough Mother to ensure you make it through the animation!

Starter Skill Loadout (Lv. 2-11)

Fiery Juggernaut

Lv	Skill	Description
2	Pineapple Express	Grab an enemy, drop a grenade down their pants, and throw them.
6	Tough Mother	Gain a temporary health boost to absorb damage from enemies and negate staggers.
9	Flaming Punch	Ignite your fist for an explosive punch.
11	Transfusion	While active, heal yourself and your friends by hurting your enemies.

Skill Loadout Merits

This skill loadout focuses on a balance of offense and defense, allowing the Boss to take down the toughest of enemies while pushing through bullets and explosions.

Pineapple Express instantly takes down Tough enemies without needing to deplete their shields. Its low cost of 1 Flow makes it easy to charge up and use at any time.

Tough Mother gives you stagger resistance and a significant health boost, allowing you to save yourself from dangerous situations or stay on the offensive. While the cost of 2 Flow is high, the survivability the skill provides is well worth it.

Flaming Punch allows you to send enemies flying with a powerful fiery blow, instantly killing weaker foes and knocking down Tough enemies. This skill is great for knocking away foes with melee weapons and comes out faster than Pineapple Express.

Transfusion heals you and your crew whenever you deal damage. This skill works as a great healing ability when Takedown isn't active, although its 2 Flow cost means that you should use this skill wisely.

Saints Row (2022) Related Guides

Beginner's Guide

Tips and Tricks Guides

Tips and Tricks Guides
Vehicle Customization	Best Boss Factory Creations
Weapon Customization	Multiplayer Guide
Character Creation Guide	Trophies & Achievements
How to Farm Money	How to Unlock Vehicle Delivery
How To Do a Barrel Roll	All Fast Travel Locations
Leveling Guide	Best Skills and Loadouts
How to Do Car to Wingsuit	Best Perks
Empire Table Guide	How to Rob Armored Trucks
How to Lose and Gain Notoriety	How to Change the Time of Day
All Pinwheel Vehicle Challenges	Post Game Content and 100% Completion Guide
Best Weapons	All PC Achievements
Best Vehicles	Best Ventures
How to Get Dustlander Weapons	How to Do a 360 Spin
How to Unlock AI Driver	What Is the Max Level?
Best Settings and Recommended Difficulty	How to Claim the Idols Anarchy Pack
How to Unlock the Helipad	How to Unlock the Boat Dock
How to Unlock and Use the Wingsuit	How to Get More Ammo
How to Unlock the Playlist	How to Change Weapons
All Weapon Visual Mods and How to Get	All Emotes, Gestures, and Dances