The Callisto Protocol features a variety of gruesome Biophage and bosses to come across as you escape Black Iron Prison. Read on to see a list of all bosses and enemies in the game and tips and guides for how to beat them!

List of Bosses

Two-Head

The Two-Head is a massive twin-headed Biophage that dishes out devastating blows with its long and heavy limbs. Check out our guide below for how to beat the Two-Head boss in each of its encounters!
How to Beat Two-Head Boss

Ferris

Captain Leon Ferris is encountered as a boss in Chapter 7: Colony and as the final boss of The Callisto Protocol at the end of Chapter 8: Tower. Check out our guide below to learn how to beat Ferris in each of his encounters!
Ferris Boss Fight Guide

List of Enemies

Regular Biophage

Description	Regular Biophages are the most common enemy type in the game, running after the player to hit them with melee attacks.
Recommended Weapon	Hand Cannon and Stun Baton

How to Beat Regular Biophages

You can easily deal with regular Biophages by dodging their attacks and fighting back with your Stun Baton and Hand Cannon.
How to Beat Biophage

Bloated Biophage

Description	Bloated Biophages are variants of Regular Biophages that take more punishment and block melee attacks more often.
Recommended Weapon	Riot Gun and Stun Baton

How to Beat Bloated Biophages

While the strategy for taking down Bloated Biophages is the same as Regular Biophages, you can wear them down faster using the Riot Gun and its high close-range damage output.

Mutated Biophage

Description	When Biophages with tentacles are left alive for too long, they transform into stronger Mutated Biophages.
Recommended Weapon	Riot Gun or Assault Rifle

How to Beat Mutated Biophages

You can prevent Mutated Biophages from spawning by immediately killing Biophages that have tentacles sprouting out of them.

However, if an enemy does fully transform into a Mutated Biophage, we recommend using the Riot Gun or Assault Rifle to quickly tear through their high health pools.

Biophage Leech

Description	Biophage Leeches are small fleshy creatures that attack the player by leaping toward their head and suffocating them.
Recommended Weapon	Hand Cannon or Tactical Pistol

How to Beat Biophage Leeches

You can take out Biophage Leeches from afar with shots from your Hand Cannon or Tactical Pistol, or you can deal with them up close by stomping them on the ground.

Spitter (Big Mouth)

Description	Spitters are large Biophages that spew out acid toward the player from its wide-open mouth.
Recommended Weapon	Hand Cannon and Stun Baton

How to Beat Spitters

You can disable the Spitters' acid attack by blowing their heads off with your Hand Cannon. Doing this forces them to only use their predictable melee attacks, making them easier to deal with.

Bloodworm

Description	Bloodworms are Biophages that hide in fleshy masses and attack the player by lunging towards them with their extremely long necks.
Recommended Weapon	Hand Cannon

How to Beat Bloodworms

Keep a close eye on your surroundings for the Bloodworms' large bulbous masses and take them out with your Hand Cannon before they have a chance to attack you.

Rusher

Description	Rushers are agile Biophages that can climb up walls and turn themselves invisible to quickly ambush the player.
Recommended Weapon	GRP and Riot Gun

How to Beat Rushers

Rushers are extremely quick and can turn themselves invisible, so we recommend using the GRP to put them out of position before blasting them with the Riot Gun up close.

The Blind

Description	The Blind are Biophages that cannot see but are extremely sensitive to sound.
Recommended Weapon	Shiv

How to Beat The Blind

The most efficient way to take out The Blind is through stealth kills with the Shiv. Sneak up behind them without making a sound and press the Interact button to instantly take them out.

Exploder

Description	Exploders are Biophages that crawl on the ground and detonate themselves when near the player or on death.
Recommended Weapon	Hand Cannon

How to Beat Exploders

Exploders are extremely fragile and die in a single shot with any of the weapons in the game. However, since they deal damage in an area upon dying, make sure to keep your distance before taking one out.

Security Bot (Security Unit)

Description	Security Units are the main enforcers of Black Iron Prison, using their heavy-duty firepower to eliminate escaping prisoners.
Recommended Weapon	Hand Cannon

How to Beat Security Bots

You can quickly take down Security Bots by repeatedly shooting them in the head, which is their primary weak spot.

However, note that Security Bots are immune to melee attacks, so stay out of their line of sight and avoid them completely if you don't have the firepower to take them out.
How to Kill Security Bots

The Callisto Protocol Related Guides

The Callisto Protocol Guide & Walkthrough

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