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The Callisto Protocol

Contagion Mode Guide

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Callisto Protocol - Contagion Mode Guide
Contagion Mode is a difficulty game mode available in the Contagion Bundle released in March 2023 for The Callisto Protocol. Read on to learn how to beat the Contagion Mode and how to unlock it!

What is Contagion Mode?

Hardest Difficulty Mode

The Callisto Protocol - Hardest Difficulty Mode

Contagion Mode is the hardest difficulty mode in The Callisto Protocol. Ammo and Health Drops are reduced to a minimum, and dying means restarting the game from the very beginning. Its gameplay restrictions are a akin to Hardcore or Permadeath modes in other games.

Contagion Mode is designed to be more punishing than the Maximum Security Difficulty Setting!

Difficulty Setting Differences

How to Unlock Contagion Mode

Contagion Bundle or Season Pass

The Callisto Protocol - Contagion Bundle

Contagion Mode can be unlocked by purchasing the Contagion Bundle DLC on your preferred platform. The bundle and its contents are also available in The Callisto Protocol Season Pass, which includes access to the Contagion Bundle, Riot Bundle, and other DLC packs.

Season Pass Price and List of Content

How to Beat Contagion Mode

Master All Techniques

You have to master all the techniques in the game, like using the GRP, dodging, blocking, and more, to survive in Contagion Mode. You can go on Minimum Security difficulty and practice with weaker enemies first before taking on the Contagion Mode.

Tips and Tricks

Memorize Every Part

The Callisto Protocol - Memorize Every Part

When playing in Contagion Mode, you are basically doing a deathless gameplay, as you will have to start over when you die. Memorize every nook, enemy spawn, chest, and item if you want to survive without dying in this hellish game mode.

Avoid Enemies if Possible

The Callisto Protocol - Avoid Enemies if Possible
If you can help it, try to avoid combat and sneak past enemies to progress. Since there is no guarantee for enemies to drop Ammo, Health Packs, or Credits, it is better to bet safely and steer clear of the enemies.

Turn On All Combat Assist Options

Settings Options
Aim Assist ON
Aim Assist Strength 3
Auto Aim ON
Auto Dodge ON
Melee Assist ON
Button Hold Assist ON
QTE Single Press ON
QTE Auto Complete ON

You can survive better in the unforgiving environment of the Contagion Mode by turning on all combat assist options. Enabling everything won't let you fear any combat encounters with the enemies in the game. However, you can still die if you're careless, even if all the combat assist options are active, so proceed with caution still.

If you want to finish the game the hard way, you can always set them off and be on your own!

Best Settings Guide

Unlock All Upgrades Through New Game+

Upload the Schematic to a Reforge Station
Contagion Mode will come out a little bit later than the New Game Plus. You can use that time window to farm and upgrade all your weapons to the max to make it a little bit easier to finish the game on Contagion Mode.

All Reforge Weapon Upgrades and Costs

The Callisto Protocol Related Guides

Callisto Protocol - Tips and Tricks

Tips and Tricks:
Beginner's Guide to The Callisto Protocol

All Tips & Tricks

Skins and Cosmetics
List of Skins How to Get the Biophage Skin
How to Get the Retro Prisoner Skin How to Get the Founder's Pack
How to Get the Prospector Skin How to Get Watchtower Skin
How to Get Outer Way Skin -
Game Mechanics & Upgrades
All Reforge Weapon Upgrades Inventory Upgrade Guide
How to Get Armor How to Heal
How to Farm Callisto Credits Ammo Farming Guide
How to Perform a Quick Kill -
Weapons & Combat
Best Upgrades Guide Gun Controls Guide
How to Dodge Melee Attacks How to Block
Best Weapons Guide Perfect Dodge Guide
System / FAQs
Difficulty Settings Guide Best Settings Guide
New Game Plus Guide Season Pass Price and Contents
All Permanent Events and Missable Content List of All Death Animations/Scenes
How to Fix Stuttering and Frame Rate Issues Can You Save the Trapped Worker?
How to Pre-Load How to Fix Low Quality Text
How to Use Photo Mode Is There a Map?
How to Reset Checkpoints Contagion Mode Guide
How to Save: Can You Turn Off Autosave? What are Beta Paths?
All Weapon Schematic Locations Ending Explained
Can You Quick Turn? Can You Skip Cutscenes?
List of Unlockables -

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