List of Puzzles | Resident Evil 3 Remake (RE3)

Train Station.jpg
This page lists all of the puzzles in the game Resident Evil 3 Remake (RE3 Remake). Read on to find where you will encounter them and their solutions!

Train Route Puzzle

Train Station.jpg
After restoring the power at the Substation, you will have to come back to the Subway Office to plan the route for the train in order to progress the story.


The Subway Control Room puzzle answer can be seen on the board in front of you. You need to connect the start and the end of the line by using the available routes for the train.

Left Right
First RE 01
Second FA 02
Third RA 03
Fourth SA 02
Fifth FO 01
★Location: Grocery Store
Chart: Downtown

Train Route Puzzle Solution

Jewel Puzzle

Jewel Monument.jpg
You can place Jewels from the Fancy Box into the Monument in the Subway Station. Everytime you place a Jewel into the Monument, you will receive an item that will help you progress the game.

Fancy Box 1

Area Map
Inside the ToyUncle Store on top of the table. You will need the lockpick to access this area.
★Location: ToyUncle Store
Chart: Downtown

Fancy Box 2

Area Map
Inside the Grocery Store near the counter. You will need the Bolt Cutters to access this area.
★Location: Grocery Store
Chart: Downtown

Fancy Box 3

Area Map
Inside the safe room in the Donut Shop.
★Location: Donut Shop
Chart: Downtown


1 Jewel Hand Grenade
2 Jewels Tactical Stock (Shotgun)
3 Jewels Hip Pouch

Where to Find the Jewels

Vaccine Puzzle

Vaccine Puzzle Banner.jpg

To create the Vaccine, you must first obtain the two solutions needed to create the Vaccine Base. These solutions can be obtained in these areas:

Culture Sample

Item Name Map
★Location: Lab 1
Chart: Nest 2

Liquid Filled Test Tube

Item Name Map
★Location: Incubation Lab
Chart: Nest 2

Once you have all the solutions, combine them and solve the puzzle using the Vaccine Equipment.


Solution Vaccine.jpg

First Second Third
Mid High Low

Vaccine Puzzle Solution

Related Links

Before Playing

Controls and Techniques Character Models
Recommended Difficulty How Long Does It Take to Beat RE3
Reviews -

Controls and Techniques

Basic Controls How to Dodge
How to Aim Quick Turn
Tips for Critical Hits Tips for Headshots

Guides & Walkthroughs

How to Cure Parasite Status Safe Codes and Locker Combinations
Item Combination List How to Combine Items
Unlockable Content How to Farm Points Fast
List of Puzzles How to Unlock Minimalist

Other Tips & Guides

Pre-order Bonuses New Features
Mr. Charlie Doll Locations All Shop Weapons and Items
Differences Between Normal and Z Versions List of Trailers
How to Unlock Nightmare and Inferno Mode How Difficult are Nightmare and Inferno Mode?

Beginner Guides

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    • Anyone still alive? Hahahaha. I hope this pandemic doesn't evolve into a zombie apocalypse.

    • I can see marketing elements in the new part of the game. Currently, it is becoming more and more popular. All in all, I am not surprised it is a way to get extra money for game developers. For more information on marketing in games, see this article:

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