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This page contains information on the vaccine puzzle in Resident Evil 3. Read on to learn what items you need, how it works, and the solution!

You will need the Adjuvant Sample and Antigen Sample to combine them into the Vaccine Base needed for the puzzle.
| Item | Map |
|---|---|
Enlarge |
Enlarge |
| ★Location: Incubation Lab ★Chart: Nest 2 |
|
| Item | Map |
|---|---|
Enlarge |
Enlarge |
| ★Location: Lab 1 ★Chart: Nest 2 |
|
EnlargeAfter getting the Vaccine Base from combining the two solutions. You will need to go back to the second floor and use the Vaccine Equipment.

To solve the puzzle you will need to get all 3 chambers to 50 using the controls below. Each control will have a mid and high level, adding a specific value to each chambers. Getting the right combination is requred to raise all chambers to the right level.
| Mid Levels | High Levels | |
|---|---|---|
| Left | 30 | 10 | 10 | 40 | 20 | 20 |
| Middle | 10 | 10 | 10 | 20 | 40 | 40 |
| Right | 40 | 30 | 20 | 40 | 40 | 20 |

Solving the puzzle requires you to press the buttons of the chambers in this order:
Left Chamber x 1 > Middle Chamber x 2
| No. | Walkthrough Section | Clear Time |
|---|---|---|
| ① | Opening | 15 minutes |
| ② | Downtown | 20 minutes |
| ③ | Substation ~ Subway Office | 40 minutes |
| ④ | Sewers ~ Subway | 40 minutes |
| ⑤ | Police Station | 30 minutes |
| ⑥ | Subway Tunnel ~ Clock Tower | 15 minutes |
| ⑦ | Hospital | 70 minutes |
| ⑧ | Underground Storage | 25 minutes |
| ⑨ | Nest 2 | 40 minutes |
| ★ | 100% Walkthrough After Clearing Story | |
Vaccine Puzzle Solution



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Easy puzzle! Don't why you have to make a guide for this one