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Titan Quest 2
Lethal Plague Rogue Build
NEW: 0.1.1 Hotfix 1 ▶︎ All Patch Notes
UPDATED: Early Access Roadmap
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This is a Lethal Plague Rogue build guide for Titan Quest 2. Check out how the Lethal Plague Rogue melee build works with their skills, equipment, attribute priorities, and playstyle here!
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List of Contents
Lethal Plague Rogue Build
Build Summary
| Build Setup | |
|---|---|
 Lethal Plague Rogue Build |
 Lethal Strike ・Deals 200% Weapon Damage to a single target. Consumes flow to deal 25% more Damage. If this skill consumes Flow or the target is killed, its cooldown is refreshed.
 Preparation ・Emit an Aura with a 18m radius.
・Aura grants you and alies 20% increased Poison Damage. ・Aura grants you and allies 20% increased Physical Damage.  Mark for Death ・Mark your target.
・When you hit the marked enemy, you deal an extra 10% of the hit as Vitality Damage. This Damage cannot critically hit. ・This effect ends, when the target is no longer your Mark.  Vanish ・Gain 30% increased Movement Speed, 30% increased Damgae for 6s.
 Accuracy ・6% increased Damage
・10% increased Critical Hit Chance  Deft Hands ・6% increased Damage
・4% increased Attack Speed ・4% increased Cast Speed  Toxin Distillation ・12% increased Poison Damage
・12% increased Plague Chance  Deadly Affliction ・8% increased Ailment Chance
・8% increased Ailment Power  Sleight of Hand ・8% increased Damage with Weapon Attacks
 Dismantling Tactics ・Deal 12% increased Damage to your Mark
・When you kill an enemy, deal 5 Vitality Damage to your Mark |
Tier Ranking:  |
|
 High Poison Burst Damage Excellent AoE Damage Lacks Survivability Requires Skill Interval Rotation | |
The Lethal Plague Rogue build focuses on spamming Lethal Strike to deal huge Poison damage with the use of its short cooldown when paired with Mark for Death. This allows your Lethal Strike to have a 1-second cooldown as long as it is hitting marked targets.
Do note that this build is made until Level 22 so you can achieve max Divinity for both classes once you complete all the quests. Any additional points after that level can be slotted into maxing out Mark for Death or more passive modifiers.
| August 13, 2025 | Lethal Plague Rogue build was created. |
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Equipment and Affixes
| Gear | Affixes | |
|---|---|---|
| Head (Medium Armor) |
・Increased Cooldown Rate
・Energy Regeneration ・Agility ・Any Elemental Resistance |
|
| Shoulders (Medium Armor) |
・Increased Ailment Power
・Increased Cooldown Rate ・Agility ・Any Elemental Resistance | |
| Torso (Medium Armor) |
・Agility
・Vigor ・Health Regeneration ・Any Elemental Resistance |
|
| Arms (Medium Armor) |
・Increased Ailment Power
・Increased Poison Damage ・Increased Ailment Chance ・Any Elemental Resistance |
|
| Legs (Medium Armor) |
・Increased Movement Speed
・Agility ・Any Elemental Resistance |
|
| Necklace | ・Increased Ailment Power
・Increased Cooldown Rate ・Agility ・Any Elemental Resistance |
|
| Ring 1 | ・Increased Ailment Power
・Weapon Poison Damage ・Increased Poison Damage ・Increased Cooldown Rate |
|
| Ring 2 | ・Increased Ailment Power
・Weapon Poison Damage ・Increased Poison Damage ・Increased Cooldown Rate |
|
| Main Weapon (Daggers) |
・Base Weapon Critical Hit Chance ・Increased Ailment Power ・Weapon Poison Damage ・Increased Poison Damage ・Increased Ailment Chance |
|
| Offhand (Daggers) |
・Base Weapon Critical Hit Chance ・Increased Ailment Power ・Weapon Poison Damage ・Increased Poison Damage ・Increased Ailment Chance |
Your equipment entirely focuses on stacking Ailment Power to increase the damage of your Plague stacks from Lethal Strike, and Poison Damage paired with Agility to maximize your damage total output. Cooldown Rate is an important affix as well, since this can shorten the 1-second cooldown of Lethal Strike after hitting a marked target.
Make sure to always pick up and equip higher level equipment as you progress so you can benefit from the increased base stats they provide.
| List of Weapons | List of Armor |
Recommended Uniques
 Venom Heart |
・X% increased Poison Damage
・+X% Poison Resistance ・+ X Weapon Poison Damage ・X% increased Ailment Chance ・X% increased Ailment Power ・X% increased Projectile Weapon Damage |
|---|---|
 Trygon's Tail |
・X% increased Pierce Damage
・X% increased Poison Damage ・+ X Weapon Pierce Damage ・+ X Weapon Poison Damage ・X% increased Cooldown Speed to Poison Abilities ・X% increased Cooldown Speed to Projectile Abilities |
We highly recommed equipping Venom Heart as this boosts both your Poison Damage and Ailment Power to match the build. Equipping two Trygon's Tail can be a good replacement weapon for more Poison Damage until you find a better Dagger with the Ailment Power affix attached to it.
Abilities and Passives
| Skills | Modifiers |
|---|---|
|
Lethal Strike
(17) |
 Mark Focus Mark Focus ・15% more Damage against your Mark. ・When this ability hits your Mark it recovers 20% of its Cooldown.  Poison Explosion Poison Explosion ・On hit deals 17 Poison Damage + 4 per Plagued stack on target in a 2m radius. ・+2 Energy cost. |
|
Preparation
(15) |
 Envenom Envenom ・Aura grants you and allies +4 Weapon Poison Damage. ・Grants you 100% Weapon Damage converted to Poison Damage. ・+30 Energy reserved.  Weapon Coating Weapon Coating ・Grants you +2 Poison Weapon Damage. ・Whenever you hit an enemy with Weapon Attacks you have a secondary 10% chance to apply Plagued. ・+15 Energy reserved. |
|
Mark for Death
(1) |
 Weaken Weaken ・The marked target deals 10% reduced Damage. ・+2 Energy cost. |
|
Vanish
(11) |
 Enhanced Ailments Enhanced Ailments ・Grants 30% increased Ailment Chance. ・Grants 8% increased Ailment Power.  Flow Gain Flow Gain ・On use gain Flow. ・+2s Base Cooldown Duration. |
|
Accuracy
(12) |
 Critical Hit Chance Critical Hit Chance ・20% increased Critical Hit Chance  Critical Hit Damage Critical Hit Damage ・+15% Critical Damage Multiplier |
|
Deft Hands
(6) |
Critical Hit Chance Critical Hit Chance ・20% increased Critical Hit Chance |
|
Toxin Distillation
(8) |
Plagued Chance Plagued Chance ・20% increased Plagued Chance ・20% increased Plagued Power Poison Damage Poison Damage ・20% increased Poison Damage ・+5% Poison Penetration |
|
Deadly Affliction
(6) |
Ailment Power Ailment Power ・20% increased Ailment Power |
|
Sleight of Hand
(6) |
Ailment Chance Ailment Chance ・30% increased Ailment Chance with Weapon Attacks |
|
Dismantling Tactics
(8) |
Critical Hit Chance Critical Hit Chance ・You have 40% increased Critical Hit Chance against your Mark |
Your main skill will be Lethal Strike, which can deal around 2k-4k burst damage on each use when paired with the Mark for Death and Vanish damage buffs. Always initially use Mark for Death on your target so you can make use of the 1 second cooldown of Lethal Strike from the Mark Focus modifier. Additionally, Preparation is for converting your weapon damage into Poison Damage so you can start inflicting Plague stacks for even higher burst damage.
As for your passives, they mostly consist of damage boosts where Toxin Distillation and Dismantling Tactics are the passives that mainly provide higher damage for this build. Critical Hit Chance is also an important damage boost since Lethal Strike can hit multiple times in one use.
Attribute Priority
| Attribute Prioritization |
|---|
| Agility ▶ Vigor |
We highly recommend focusing on Agility for the majority of your attribute points, as this significantly boosts your Poison Damage and enables equipping of Light and Medium armor. As you progress, always add 1 Vigor for every 2 Agility you invest in to keep a 1:2 ratio between the stats.
Playstyle and Skill Rotation
The Lethal Plague Rogue build revolves around spamming Lethal Strike to deal huge Poison damage with the help of Mark for Death and Vanish to increase the damage output further. The rotation is as follows:
- Toggle on Preparation for more Poison damage and Plague procs.
- Cast Mark for Death on your target to enable Lethal Strike's short cooldown.
- Use Vanish to gain Flow for the increased damage buff and Ailment Power.
- Immediately spam Lethal Strike on your marked target to deal huge Poison and Plague damage.
Titan Quest 2 Related Guides
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Lethal Plague Rogue |
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Lethal Plague Rogue Build
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